Ru-TRZ2
Ru-TRZ2 is a potent ruthenium-based chemotherapeutic agent. Ru-TRZ2 induces apoptosis and necroptosis. Ru-TRZ2 shows antitumor activity.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C45H43F6N4O7P2RuS2
- 分子量:1092.98
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Ru-TRZ2 (72 h) induces necroptosis with IC50s of 0.45, 0.24 µM for HCT116, HT29 cells, respectively[1].
Ru-TRZ2 induces mitochondrial depolarization and apoptotic cell death in HT29 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HT29 cells
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Concentration:10 μM
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Incubation Time:24 h
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Result:Induced apoptosis and increased the expression of cleaved PARP.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:8-10 weeks, Male nude mice[1]
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Dosage:5 mg/kg
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Administration:I.v.; every 2 days for 10 injections
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Result:Decreased the tumor weight in HT29 xenograft mice.
化学情報
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分子量 1092.98
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分子式 C45H43F6N4O7P2RuS2
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SMILES
FC(F)(F)S(=O)([O-])=O.CN(C(CCC)=O)/N=N/C1=CC=C(C#[N][Ru+2]2([])[P](C3=CC=CC=C3)(C4=CC=CC=C4)CC[P]2(C5=CC=CC=C5)C6=CC=CC=C6)C=C1.FC(F)(F)S(=O)([O-])=O.C7CCCC7
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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データシート (271 KB)
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SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
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