Explore the evolution from GLP-1 mono-agonists to multi-receptor therapeutics and the expanding role of incretin-based therapies in precision metabolic medicine.
サイエンスレビュー
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Explore the limitations of conventional virtual screening, advances in AI-enabled molecular discovery, and their impact on early-stage drug discovery. -
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Explore lessons from KRAS G12C inhibitors, advances from G12D to Pan-RAS targeting, and emerging strategies to overcome resistance and reshape the tumor microenvironment. -
Explore CRC molecular subtypes, immune landscapes, resistance mechanisms, and emerging precision strategies for improving outcomes across distinct subtypes. -
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Explore AOC design principles, delivery challenges, and clinical advances that are expanding the reach of precision RNA medicine. -
Review the transition from Casgevy to next-generation base editing, focusing on technological advances, delivery challenges, and the future of programmable medicine. -
Explore MS-based proteomics through sample preparation workflows, quantification strategies, and applications in cancer research. -
Review the mechanisms, mitochondrial regulation, disease relevance, and translational opportunities of the NLRP3–STING axis in neuroinflammation. -
Explore lysosomal nutrient sensing, quality control, cellular adaptation, disease mechanisms, and emerging therapeutic approaches. -
Explore the dual role of cellular senescence in cancer, including tumor suppression, SASP-driven tumor promotion, senescence heterogeneity and plasticity, and advances in senescence-targeted therapies.