319 Results for "

mAbs

" in MedChemExpress (MCE) Product Catalog:
Products (319)

319 Results for "mAbs" in MCE Product Catalog:

10
10 Publications Verification
製品番号: HY-108730
CAS 番号: 1537032-82-8
別名: Anti-Human PD-L1, Human Antibody; MSB 0010718C; MSB0010718C

Target:  

PD-1/PD-L1

研究分野:  

Inflammation/Immunology Cancer

Avelumab (Anti-Human PD-L1) a fully human IgG1 anti-PD-L1 monoclonal antibody (mAb) with potential antibody-dependent cell-mediated cytotoxicity (ADCC). Avelumab enhances ADCC on several cancer cell lines expressing PD-L1. Avelumab can be used for the study of chordoma .
10
10 Publications Verification
製品番号: HY-108730A
CAS 番号: 1537032-82-8
純度:  96.02%

Target:  

PD-1/PD-L1

研究分野:  

Inflammation/Immunology Cancer

Avelumab (anti-PD-L1) a fully human IgG1 anti-PD-L1 monoclonal antibody (mAb) with potential antibody-dependent cell-mediated cytotoxicity (ADCC). Avelumab (anti-PD-L1) enhances ADCC on several cancer cell lines expressing PD-L1. Avelumab (anti-PD-L1) can be used for the study of chordoma .
6
6 Cited Publications
製品番号: HY-P9926
CAS 番号: 1190264-60-8
別名: REGN-668; SAR-231893

Target:  

Interleukin Related

研究分野:  

Inflammation/Immunology Cancer

Dupilumab (REGN-668) is a fully human mAb to IL-4 receptor α (IL-4Rα) that inhibits both IL-4 and IL-13 signaling, markedly improved moderate-to-severe atopic dermatitis .
5
5 Cited Publications
製品番号: HY-P99032
CAS 番号: 1228763-95-8
別名: IPH2201
Monalizumab (IPH2201) is an immune checkpoint inhibitor targeting Natural Killer Group 2A (NKG2A). Monalizumab, a humanized anti-NKG2A blocking mAb, increases IFN-γ production, thereby promoting NK cell effector functions. Monalizumab can be used for the research of head and neck squamous cell carcinoma (HNSCC) .
5
5 Cited Publications
製品番号: HY-15971A
CAS 番号: 185991-24-6
別名: GENZ-644494
Target:  

CXCR HIV

研究分野:  

Infection Endocrinology

AMD 3465 (GENZ-644494) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12 AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells; AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM), but has no effect on CCR5-using (R5) viruses.
5
5 Cited Publications
製品番号: HY-15971
CAS 番号: 185991-07-5
別名: GENZ-644494 hexahydrobromide
Target:  

CXCR HIV

研究分野:  

Infection Endocrinology

AMD 3465 hexahydrobromide (GENZ-644494 hexahydrobromide) is a potent antagonist of CXCR4, inhibits binding of 12G5 mAb and CXCL12 AF647 to CXCR4, with IC50s of 0.75 nM and 18 nM in SupT1 cells; AMD 3465 also potently inhibits the replication of X4 HIV strains (IC50: 1-10 nM), but has no effect on CCR5-using (R5) viruses.
5
5 Cited Publications
製品番号: HY-P99340
CAS 番号: 2423014-07-5
別名: VIR 7831; GSK-4182136

Target:  

SARS-CoV

研究分野:  

Infection Cancer

Sotrovimab (VIR 7831) is a human IgG1κ pan-sarbecovirus monoclonal antibody (mAb), neutralizes SARS-CoV-2, SARS-CoV-1, and multiple other sarbecoviruses. Sotrovimab is developed based on S309, exhibits a long half-life and great bioavailability in the respiratory mucosa. Sotrovimab could result in immune-mediated viral clearance and prevent progression of Covid-19 early in the course of disease .
4
4 Cited Publications
製品番号: HY-P9971
CAS 番号: 1798286-48-2
別名: SHR-1210; INCSHR1210

Target:  

PD-1/PD-L1

研究分野:  

Cancer

Camrelizumab (SHR-1210) is a potent humanied high-affinity IgG4-κ monoclonal antibody (mAb) to PD-1. Camrelizumab binds PD-1 at a high affinity of 3 nM and inhibits the binding interaction of PD-1 and PD-L1 with an IC50 of 0.70 nM. Camrelizumab acts as anti-PD-1/PD-L1 agent and can be used for cancer research, including NSCLC, ESCC, Hodgkin lymphoma, and advanced HCC et,al .
3
3 Cited Publications
製品番号: HY-P99006
CAS 番号: 931402-35-6
別名: MORab-009

Target:  

Mesothelin

研究分野:  

Cancer

Amatuximab (MORab-009) is a chimeric, humanized IgG1/k MAb that targets the cell surface mesothelin (MSLN). Mesothelin is a glycosylphosphatidyl inositol (GPI)-anchored membrane glycoprotein, which is present in a restricted set of normal adult tissues such as the mesothelium .
2
2 Cited Publications
製品番号: HY-P99100
CAS 番号: 2556646-63-8
別名: CTL-002

研究分野:  

Cancer

Visugromab (CTL-002) is a GDF-15 neutralizing IgG4 mAb. Visugromab has synergistic anticancer activity with the anti-PD1 antibody Nivolumab (HY-P9903) and can effectively act on PD-1/PD-L1 relapsed/refractory metastatic solid tumors. Recommend Isotype Controls: Human IgG4 (S228P) kappa, Isotype Control (HY-P99003) .
2
2 Cited Publications
製品番号: HY-P99661
CAS 番号: 2135939-52-3

Target:  

Interleukin Related

研究分野:  

Cancer

Inbakicept is a dimeric human IL-15 receptor alpha (IL-15 Ra) sushi domain/human IgG1 Fc fusion protein and is an IL-15 superagonist complex. Inbakicept is able to form complex N-803 (Nogapendekin alfa inbakicept) with the IL-15 antibody Nogapendekin alfa in a 1:2 ratio. N-803 mimics the function of IL-15 and amplifies anti-CD20 mAb-mediated NK cell responses and antibody-dependent cellular cytotoxicity (ADCC). N-803 also increases degranulation and IFNγ production in cells .
1
1 Cited Publications
製品番号: HY-P9801
別名: SARS-CoV-2 (2019-nCoV) Spike RBD Antibody

Target:  

SARS-CoV

研究分野:  

Infection

Anti-Spike-RBD mAb is a CHO cell derived human monoclonal IgG1 antibody. Blocking the interaction of Spike protein and ACE2. Anti-Spike-RBD mAb is a potential therapeutic approach for SARS-CoV-2 treatment .
1
1 Cited Publications
製品番号: HY-P99113
CAS 番号: 1299440-37-1
別名: MEDI-551
Inebilizumab is an anti-CD19 monoclonal antibody (mAb) with enhanced antibody-dependent cell-mediated cytotoxicity against B cells. Inebilizumab can be used for multiple sclerosis and neuromyelitis optica research .
1
1 Cited Publications
製品番号: HY-P99434
CAS 番号: 2378692-15-8
別名: KY1005; SAR445229

Target:  

阻害性抗体

研究分野:  

Inflammation/Immunology

Amlitelimab () is an anti-OX40 Ligand (OX40L) monoclonal antibody (mAb). Amlitelimab inhibits OX40-OX40L interaction, and can be used in the research of atopic dermatitis .
1
1 Cited Publications
製品番号: HY-12843
CAS 番号: 189232-42-6
純度:  98.93%
Target:  

CDK ERK

研究分野:  

Cancer

Bohemine is a purine analogue and is a synthetic and selective CDK inhibitor with IC50s of 4.6 μM, 83 μM, and 2.7 μM for Cdk2/cyclin E, Cdk2/cyclin A, and Cdk9/cyclin T1, respectively. Bohemine also inhibits ERK2 with an IC50 of 52 μM and has less inhibitory effect on CDK1, CDK4 and CDK6. Bohemine has a broad spectrum anti-cancer activities .
1
1 Cited Publications
製品番号: HY-P99253
CAS 番号: 1159266-37-1
別名: KW-0761

Target:  

CCR

研究分野:  

Inflammation/Immunology Cancer

Mogamulizumab (KW-0761) is a recombinant anti-CCR4 monoclonal antibody (MAb). Mogamulizumab can eliminate tumor cells by antibody-dependent cellular cytotoxicity (ADCC). Mogamulizumab can be used in the research of cancers, adult T-cell leukemia/lymphoma (ATLL), cutaneous T-cell lymphoma (CTCL) .
1
1 Cited Publications
製品番号: HY-P990110
別名: Mab158

Target:  

Amyloid-β

研究分野:  

Neurological Disease

Lecanemab (Mouse IGG2a) (Mab158) is a monoclonal antibody that targets soluble β-amyloid and has the potential to reduce cognitive decline. The variable region of Lecanemab (Mouse IGG2a) is consistent with that of Lecanemab, while the constant region is of Mouse IGG2a sequence. Lecanemab (Mouse IGG2a) almost abolishes accumulation in astrocytes and rescues neurons from Aβ-induced cell death. Lecanemab (Mouse IGG2a) holds promise for research in the field of Alzheimer's disease .
1
1 Cited Publications
製品番号: HY-P99025
CAS 番号: 953400-68-5
別名: TNX-650; MILR1444A; RG3637

Target:  

Interleukin Related

研究分野:  

Inflammation/Immunology

Lebrikizumab (TNX-650) is an IgG4 humanized anti-interleukin-13 (IL-13) mAb with anti-itch effects that specifically binds to IL-13 in a non-receptor binding domain and inhibits its function. Lebrikizumab inhibits the IL-13 driven Th2 inflammatory response and blocks the signaling of IL-4Rα/IL-13Rα1. Lebrikizumab can be used for the research of asthma, atopic dermatitis and neuroinflammatory diseases .
1
1 Cited Publications
製品番号: HY-P991447

Target:  

VISTA

研究分野:  

Cancer

Anti-VSIR/VISTA Antibody (SG7) is a human monoclonal antibody (mAb) targeting VISTA/B7-H5. Anti-VSIR/VISTA Antibody (SG7) inhibits VISTA function and prevents PSGL-1 and VSIG3 from binding to VISTA. Anti-VSIR/VISTA Antibody (SG7) has anti-tumor activity in the mouse B16F10 melanoma model. Recommended isotype control: Human IgG1 kappa, Isotype Control (HY-P99001) .
1
1 Cited Publications
製品番号: HY-P990121

Target:  

Interleukin Related

研究分野:  

Inflammation/Immunology Cancer

Anti-Mouse IL-4 Antibody (11B11) is an anti-mouse IL-4 IgG1 monoclonal antibody. Anti-Mouse IL-4 Antibody (11B11) can inhibit Th2 cell differentiation by blocking the IL-4 signaling pathway. Anti-Mouse IL-4 Antibody (11B11) can significantly reduce fibrosis combined with anti-IL13 mAb. Anti-Mouse IL-4 Antibody (11B11) can be used for researches on cancer and inflammation conditions such as colorectal cancer and prostatitis .