931402-35-6
931402-35-6
Chemical Structure
Amatuximab
Synonym(s): MORab-009
- CAS No.: 931402-35-6
- Formula:N/A
- Molecular Weight:(144.363 kDa)
SMILES: [Amatuximab]
Biological Activity: Amatuximab (MORab-009) is a chimeric, humanized IgG1/k MAb that targets the cell surface mesothelin (MSLN). Mesothelin is a glycosylphosphatidyl inositol (GPI)-anchored membrane glycoprotein, which is present in a restricted set of normal adult tissues such as the mesothelium[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Amatuximab | 99.90% | Amatuximab (MORab-009) is a chimeric, humanized IgG1/k MAb that targets the cell surface mesothelin (MSLN). Mesothelin is a glycosylphosphatidyl inositol (GPI)-anchored membrane glycoprotein, which is present in a restricted set of normal adult tissues such as the mesothelium. | ||||||||||||||||||||
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References
- [1]. Hassan R, et al. Phase II clinical trial of amatuximab, a chimeric antimesothelin antibody with pemetrexed and cisplatin in advanced unresectable pleural mesothelioma. Clin Cancer Res. 2014;20(23):5927-5936. [Content Brief]
- [2]. Baldo P, et al. Amatuximab and novel agents targeting mesothelin for solid tumors. Onco Targets Ther. 2017;10:5337-5353. Published 2017 Nov 8. [Content Brief]
Keywords
