Sucrose dilaurate
Sucrose dilaurate acts as an emulsifier, dispersant and stabilizer. Sucrose dilaurate reduces the release of HMGB1 from UVB-irradiated keratinocytes. Sucrose dilaurate inhibits melanogenesis and decreases bilirubin levels. Sucrose dilaurate induces autophagy in human epidermal keratinocytes, thereby reducing carboxymethyl lysine (CML) levels. Sucrose dilaurate reduces the secretion of insulin-like growth factor-binding protein 3 (IGFBP3) and nerve growth factor (NGF) by senescent keratinocytes. Sucrose dilaurate is investigated as an emulsifier, dispersant or stabilizer in the cosmetics, food and pharmaceutical industries.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 25915-57-5
- 分子式: C36H66O13
- 分子量:706.90
-
保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
生物活性
-
化学情報
- 純度とドキュメンテーション
- 参考文献
-
Help & FAQs
生物活性
Sucrose dilaurate (as a component of the SDL combination, a mixture of Sucrose dilaurate and sucrose dilaurate at a ratio of approximately 6:4) significantly reduces bilirubin levels when incubated in a cell-free system, inhibits hydrogen peroxide-induced bilirubin production in human tKC keratinocytes, decreases intracellular bilirubin levels in HaCaT keratinocytes, and reduces skin-bound bilirubin levels in human skin sections[2].
Sucrose dilaurate (0.005%; 24 h) significantly induces autophagosome formation in neonatal human epidermal keratinocytes[3].
Sucrose dilaurate (0.01%; 24 h) significantly reduces CML levels in glyceraldehyde-glycosylated neonatal human epidermal keratinocytes[3].
Sucrose dilaurate (0.001%; 72 h) significantly inhibits the release of IGFBP3 and NGF from doxorubicin-induced senescent HaCaT keratinocytes[4].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:doxorubicin-induced senescent HaCaT keratinocytes
-
Concentration:0.001%
-
Incubation Time:72 h
-
Result:Significantly suppressed the release of IGFBP3 from senescent HaCaT keratinocytes to levels similar to those released by normal keratinocytes.
Significantly suppressed the release of NGF from senescent HaCaT keratinocytes.
化学情報
-
CAS 番号 25915-57-5
-
分子量 706.90
-
分子式 C36H66O13
-
SMILES
O=C(CCCCCCCCCCC)OC[C@]1(O[C@@H]([C@H]([C@@H]1OC(CCCCCCCCCCC)=O)O)CO)O[C@H]2O[C@@H]([C@H]([C@@H]([C@H]2O)O)O)CO
-
輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Wang J, et al. The combination of sucrose dilaurate and sucrose laurate suppresses HMGB1: an enhancer of melanocyte dendricity and melanosome transfer to keratinocytes. J Eur Acad Dermatol Venereol. 2022;36 Suppl 3:3-11. [Content Brief]
[2]. Fang B, et al. A Potential Role of Keratinocyte-Derived Bilirubin in Human Skin Yellowness and Its Amelioration by Sucrose Laurate/Dilaurate. Int J Mol Sci. 2022;23(11):5884. Published 2022 May 24. [Content Brief]
[3]. Laughlin T, et al. Autophagy activators stimulate the removal of advanced glycation end products in human keratinocytes. J Eur Acad Dermatol Venereol. 2020;34 Suppl 3:12-18. [Content Brief]
[4]. Hakozaki T, et al. Over-Represented Senescent Keratinocytes in Hyperpigmented Spots Promote Melanocyte Activation via IGFBP3 and NGF. Int J Mol Sci. 2025;26(21):10724. Published 2025 Nov 4. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Sucrose dilaurate 関連分類
HY-182824 関連分類
Powered by Bioz