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Cat. No.: HY-158072

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DOTAM-NHS-ester

DOTAM-NHS-ester is a bifunctional chelator and a macrocyclic DOTA derivative used for tumor pre-targeting. DOTAM-NHS-ester combines the efficient metal chelating ability of DOTAM macrocyclic ligands with the bioconjugation function of NHS ester active groups, and can be widely used in the biomedical field for metal labeling, molecular imaging and drug delivery development.

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CAS No.: 2236057-47-7
화학식: C₂₀H₃₄N₈O₇
분자량:498.53

보관:

-20°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Data Sheet (270 KB)

DOTAM-NHS-ester Chemical Structure

CAS No.: 2236057-47-7

사이즈

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수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

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One-Stop Platform：From Independent R&D to Pilot-Scale Production

Biological Activity
- 제품 설명
- IC₅₀ & Target
- In Vitro
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

IC₅₀ & Target^[1]

RDC Bifunctional Chelator

All Radionuclide-Drug Conjugates (RDCs) Isoforms :

In Vitro

DOTAM-NHS ester (composed of DOTAM and NHS ester) is a chelator that forms stable complexes with various metal ions and reacts with amino groups to form stable amide bonds; it is used as a biomolecule labeling reagent to introduce DOTAM into biomolecules for localization and tracking, applied to prepare metal ion-labeled probes for bioimaging, and serves as a contrast agent to improve imaging contrast and resolution by binding to specific biomolecules^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2236057-47-7
Appearance Solid
분자량 498.53
화학식 C₂₀H₃₄N₈O₇
Color White to off-white
SMILES

O=C(ON1C(CCC1=O)=O)CN2CCN(CC(N)=O)CCN(CC(N)=O)CCN(CC(N)=O)CC2
선적

Room temperature in continental US; may vary elsewhere.
보관

-20°C, protect from light, stored under nitrogen

* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Malmberg E, et al. Comparative evaluation of synthetic anti-HER2 Affibody molecules site-specifically labelled with ¹¹¹In using N-terminal DOTA, NOTA and NODAGA chelators in mice bearing prostate cancer xenografts[J]. European Journal of Nuclear Medicine and Molecular Imaging, 2012, 39(3): 481-492.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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