WDR24 - WD repeat domain 24 Gene

Also Known as JFP7; C16orf21

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 84219

About WDR24

This gene has 4 transcripts (splice variants), 207 orthologues and 9 paralogues. Ubiquitous expression in testis (RPKM 5.5), spleen (RPKM 3.4) and 25 other tissues.

Summary

Involved in cellular response to amino acid starvation; positive regulation of TOR signaling; and regulation of Autophagy. Located in cytosol and lysosomal membrane. Part of GATOR2 complex. [provided by Alliance of Genome Resources, Apr 2022]

WDR24 Products (1)

mRNA Protein Name
NM_032259.4 NP_115635.1 GATOR complex protein WDR24

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables protein binding IPI
IPI: Inferred from physical interaction
16189514 GOA
enables ubiquitin protein ligase activity IDA
IDA: Inferred from direct assay
36528027 GOA
Biological Process GO Annotation Evidence References Source
involved in cellular response to amino acid starvation IMP
IMP: Inferred from mutant phenotype
23723238 GOA
involved in cellular response to nutrient levels IDA
IDA: Inferred from direct assay
35831510 GOA
involved in positive regulation of TOR signaling IMP
IMP: Inferred from mutant phenotype
27166823 GOA
involved in positive regulation of TORC1 signaling IDA
IDA: Inferred from direct assay
35831510 GOA
involved in positive regulation of TORC1 signaling IMP
IMP: Inferred from mutant phenotype
36577058 GOA
involved in protein K6-linked ubiquitination IDA
IDA: Inferred from direct assay
36528027 GOA
involved in regulation of autophagy IMP
IMP: Inferred from mutant phenotype
27166823 GOA
Cellular Component GO Annotation Evidence References Source
part of GATOR2 complex IDA
IDA: Inferred from direct assay
35831510 GOA
located in lysosomal membrane IDA
IDA: Inferred from direct assay
28199306 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WDR24 Protein Structure

WD40

WD40: WD domain, G-beta repeat (176 - 211)

WD40

WD40: WD domain, G-beta repeat (329 - 366)

WD40

WD40: WD domain, G-beta repeat (422 - 453)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 920 a.a.
Protein Preferred Names Protein Names

GATOR complex protein WDR24

  • WD repeat-containing protein 24

WDR24 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
WDR24 Q96S15 SZT2 Homo sapiens Q5T011
Anti Bait CoIP
28199315
Intra
WDR24 Q96S15 SZT2 Homo sapiens Q5T011
Crosslink
28199315
Intra
WDR24 Q96S15 SESN3 Homo sapiens P58005
Anti Tag CoIP
26449471
Intra
WDR24 Q96S15 SESN3 Homo sapiens P58005
Anti Tag CoIP
25263562
Intra
WDR24 Q96S15 WDR59 Homo sapiens Q6PJI9
Anti Tag CoIP
25263562
Intra
WDR24 Q96S15 WDR59 Homo sapiens Q6PJI9
Anti Tag CoIP
28199315
Intra
WDR24 Q96S15 WDR59 Homo sapiens Q6PJI9
Anti Bait CoIP
28199315
Intra
WDR24 Q96S15 WDR59 Homo sapiens Q6PJI9
GMS
28199315
Intra
WDR24 Q96S15 WDR59 Homo sapiens Q6PJI9
Crosslink
28199315
Intra
WDR24 Q96S15 MIOS Homo sapiens Q9NXC5
Anti Bait CoIP
25263562
Intra
WDR24 Q96S15 MIOS Homo sapiens Q9NXC5
Anti Tag CoIP
25263562
Intra
WDR24 Q96S15 MIOS Homo sapiens Q9NXC5
Anti Bait CoIP
26449471
Intra
WDR24 Q96S15 MIOS Homo sapiens Q9NXC5
Anti Bait CoIP
28199315
Intra
WDR24 Q96S15 MIOS Homo sapiens Q9NXC5
Anti Bait CoIP
26972053
Intra
WDR24 Q96S15 MIOS Homo sapiens Q9NXC5
Anti Tag CoIP
28199315
Intra
WDR24 Q96S15 MIOS Homo sapiens Q9NXC5
Anti Tag CoIP
26972053
Intra
WDR24 Q96S15 MIOS Homo sapiens Q9NXC5
Anti Tag CoIP
26586190
Intra
WDR24 Q96S15 MIOS Homo sapiens Q9NXC5
Anti Tag CoIP
26449471
Intra
WDR24 Q96S15 SESN2 Homo sapiens P58004
Anti Tag CoIP
26449471
Intra
WDR24 Q96S15 SESN2 Homo sapiens P58004
Anti Tag CoIP
26586190
Intra
WDR24 Q96S15 SESN2 Homo sapiens P58004
Anti Bait CoIP
25263562
Intra
WDR24 Q96S15 SESN2 Homo sapiens P58004
Anti Tag CoIP
28199315
Intra
WDR24 Q96S15 SESN2 Homo sapiens P58004
Anti Tag CoIP
25263562
Intra
WDR24 Q96S15 SESN2 Homo sapiens P58004
Anti Bait CoIP
26449471
Intra
WDR24 Q96S15 SESN2 Homo sapiens P58004
Anti Bait CoIP
26972053
Intra
WDR24 Q96S15 APPBP2 Homo sapiens Q92624
Y2H Prey Pooling
25416956
Intra
WDR24 Q96S15 APPBP2 Homo sapiens Q92624
Y2H Array
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. 상품명
효과
Purity
Rare Diseases
HY-RS15768 WDR24 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus WDR24 MGD MGI:2446285
Canis familiaris WDR24 VGNC VGNC:48356
Rattus norvegicus WDR24 RGD RGD:1304803
Bos taurus WDR24 VGNC VGNC:36887
Macaca mulatta WDR24 VGNC VGNC:79289
Felis catus WDR24 VGNC VGNC:67021
Others WDR24 NCBI