Moxetumomab
Based on 1 Customer Validation
Moxetumomab is a CD22-targeting monoclonal antibody that forms the component of Moxetumomab Pasudotox, a recombinant CD22-targeting immunotoxin. Moxetumomab binds to CD22 on malignant B cells and delivers the PE38 toxin domain to tumor cells. Moxetumomab can be used in research on relapsed or refractory hairy cell leukemia.
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- Purity: 99.77%
- CAS No.: 1622075-65-3
- 분자량:146.14 kDa
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Human IgG1 kappa
Human
Siglec-2/CD22
Moxetumomab pasudotox is a CD22-targeted recombinant immunotoxin (scFv-PE38) that induces apoptosis by binding to CD22 on the surface of HCL cells and delivering Pseudomonas exotoxin PE38 to block EF-2 protein synthesis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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IgG1-kappa
ELISA, FACS, Functional assay
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Immobilized Siglec-2/CD22 Protein, Human (512a.a, HEK293, His, HY-P73648) can bind Moxetumomab. The EC50 for this effect is 7.491 ng/mL. -
Flow Cytometry analysis of Raji cells labelling Siglec-2/CD22 (red) with Moxetumomab (anti-Siglec-2/CD22) (HY-P99034). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001). Black-Unlabelled control, cells without incubation with primary antibody.
Chemical Information
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CAS No. 1622075-65-3
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Appearance Liquid
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분자량 146.14 kDa
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Color Colorless to light yellow
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SMILES
[Moxetumomab]
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선적
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
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Data Sheet (256 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)