Moxetumomab
Based on 1 Customer Validation
Moxetumomab is a CD22-targeting monoclonal antibody that forms the component of Moxetumomab Pasudotox, a recombinant CD22-targeting immunotoxin. Moxetumomab binds to CD22 on malignant B cells and delivers the PE38 toxin domain to tumor cells. Moxetumomab can be used in research on relapsed or refractory hairy cell leukemia.
For research use only. We do not sell to patients.
- Purity: 99.77%
- CAS No.: 1622075-65-3
- Molecular Weight:146.14 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
Human IgG1 kappa
Human
Siglec-2/CD22
Moxetumomab pasudotox is a CD22-targeted recombinant immunotoxin (scFv-PE38) that induces apoptosis by binding to CD22 on the surface of HCL cells and delivering Pseudomonas exotoxin PE38 to block EF-2 protein synthesis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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IgG1-kappa
ELISA, FACS, Functional assay
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Immobilized Siglec-2/CD22 Protein, Human (512a.a, HEK293, His, HY-P73648) can bind Moxetumomab. The EC50 for this effect is 7.491 ng/mL. -
Flow Cytometry analysis of Raji cells labelling Siglec-2/CD22 (red) with Moxetumomab (anti-Siglec-2/CD22) (HY-P99034). Goat Anti-Human IgG (Alexa Fluor 488) (HY-P83776) at a dilution of 1/1000 was used as the secondary antibody. Blue-Human IgG1 kappa (HY-P99001). Black-Unlabelled control, cells without incubation with primary antibody.
Chemical Information
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CAS No. 1622075-65-3
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Appearance Liquid
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Molecular Weight 146.14 kDa
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Color Colorless to light yellow
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SMILES
[Moxetumomab]
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (256 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)