XMD8-92 and JWG-045 exhibit anti-ferroptotic activities, independently of inhibiting ERK5

  • Sci Rep. 2026 Feb 28. doi: 10.1038/s41598-026-42079-w.
Wei Zhang  1  2 ,  Karmern Kan  1 ,  Aidan B Pidd  3 ,  Gala Konteva  1 ,  Weitao Xiao  1 ,  Adam J Pearson  1 ,  Zejia Song  4 ,  Qiuping Xu  5 ,  Sam Butterworth  3 ,  Alan J Whitmarsh  6 ,  Cathy Tournier  7
Affiliations
  • 1. Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health (FBMH), University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK.
  • 2. Turku Bioscience Centre, University of Turku and Åbo Akademi University, Turku, Finland.
  • 3. Division of Pharmacy and Optometry, School of Health Sciences, FBMH, University of Manchester, Manchester, UK.
  • 4. Institute of Biomedicine, University of Turku, Turku, 20520, Finland.
  • 5. Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Guangdong-Hong Kong Joint Laboratory for RNA medicine, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
  • 6. Division of Molecular and Cellular Function, School of Biological Sciences, FBMH, University of Manchester, Manchester, UK.
  • 7. Division of Cancer Sciences, School of Medical Sciences, Faculty of Biology, Medicine and Health (FBMH), University of Manchester, Michael Smith Building, Oxford Road, Manchester, M13 9PT, UK. [email protected].
PMID: 41764307 DOI: 10.1038/s41598-026-42079-w
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