SARS-CoV-2-IN-7
Based on 1 Customer Validation
SARS-CoV-2-IN-7 inhibits viral replication with a nanomolar IC50 value (844 nM) in SARS-CoV-2-infected Vero E6 cells.
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- Purity: 98.84%
- CAS No.: 2570461-66-2
- 화학식: C14H8F3NOSe
- 분자량:342.17
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보관:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HaCaT | IC50 |
>32 μM
Compound: 2a9
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Cytotoxicity against human HaCaT cells
Cytotoxicity against human HaCaT cells
|
[PMID: 35099959] |
Chemical Information
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CAS No. 2570461-66-2
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Appearance Solid
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분자량 342.17
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화학식 C14H8F3NOSe
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Color Light yellow to orange
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SMILES
O=C1C2=CC=CC=C2[Se]N1C3=CC=CC(C(F)(F)F)=C3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
용액&용해도
DMSO : 250 mg/mL (730.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
순도&문서
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Data Sheet (272 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9225 mL | 14.6126 mL | 29.2252 mL | 73.0631 mL |
| 5 mM | 0.5845 mL | 2.9225 mL | 5.8450 mL | 14.6126 mL | |
| 10 mM | 0.2923 mL | 1.4613 mL | 2.9225 mL | 7.3063 mL | |
| 15 mM | 0.1948 mL | 0.9742 mL | 1.9483 mL | 4.8709 mL | |
| 20 mM | 0.1461 mL | 0.7306 mL | 1.4613 mL | 3.6532 mL | |
| 25 mM | 0.1169 mL | 0.5845 mL | 1.1690 mL | 2.9225 mL | |
| 30 mM | 0.0974 mL | 0.4871 mL | 0.9742 mL | 2.4354 mL | |
| 40 mM | 0.0731 mL | 0.3653 mL | 0.7306 mL | 1.8266 mL | |
| 50 mM | 0.0585 mL | 0.2923 mL | 0.5845 mL | 1.4613 mL | |
| 60 mM | 0.0487 mL | 0.2435 mL | 0.4871 mL | 1.2177 mL | |
| 80 mM | 0.0365 mL | 0.1827 mL | 0.3653 mL | 0.9133 mL | |
| 100 mM | 0.0292 mL | 0.1461 mL | 0.2923 mL | 0.7306 mL |
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