Tau-aggregation-IN-5
Tau-aggregation-IN-5 is a Tau-aggregation inhibitor (EC50 = 0.31 μM). Tau-aggregation-IN-5 targets P4HB covalently and activates mild ER stress. Tau-aggregation-IN-4 can be used for the study of neurodegenerative disorders such as Alzheimer’s and Pick’s diseases.
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- CAS No.: 1283397-08-9
- 화학식: C15H13N3O
- 분자량:251.28
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- 순도&문서
- References
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Help & FAQs
Biological Activity
Tau-aggregation-IN-5 (Compound 2a) (0.008-10 μM,) dose-dependently clears tau accumulation in human induced pluripotent stem cell (hiPSC)-derived neurons, with an EC50 of 190 nM and a maximum clearance rate exceeding 90%[1].
Tau-aggregation-IN-5 (3 μM, 24 h) does not affect the level of non-aggregated tau protein in SH-SY5Y cells[1].
Tau-aggregation-IN-5 (10 μM, 6 hours) results in significant changes in the expression of 590 genes in 22,537 transcripts in SH-SY5Y cells, including ERO1B, HSPA5, and HERPUD1[1].
Tau-aggregation-IN-5 (10 μM, 2-6 h) significantly upregulates the ERAD-associated protein HERPUD1 in SH-SY5Y cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1283397-08-9
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분자량 251.28
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화학식 C15H13N3O
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SMILES
O=C(C1=CNC2=C1C=CC(N)=C2)NC3=CC=CC=C3
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Tau-aggregation-IN-5 Related Classifications
HY-176936 Related Classifications
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