2 Results for "

TRIM65

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "TRIM65" in MCE Product Catalog:

1
Kumatakenin
Kumatakenin
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1 Cited Publications
Cat. No.: HY-N3415
CAS No.: 3301-49-3
Category:  

Flavonols Flavonoids Myrtaceae Phenols Polyphenols Plants Disease Research Fields Syzygium aromaticum Cancer

Target:  

Apoptosis Autophagy Caspase Ferroptosis SARS-CoV

Kumatakenin is an orally active apoptosis inducer and autophagy inhibitor, with a Kd value of 2.94 μM for mouse ATG5. Kumatakenin increases the activities of caspase-3, caspase-8 and caspase-9, thereby inducing caspase-dependent apoptosis in ovarian cancer cells. Kumatakenin reduces the expression of chemokines and pro-oncogenic factors in ovarian cancer cells, and inhibits M2 macrophage polarization. Kumatakenin inactivates TRIM65 function, reduces the expression and stability of FASN, and thus inhibits the proliferation, migration, invasion and tumor progression of esophageal cancer cells. Kumatakenin interacts with ATG5 to reduce its protein level, decrease LC3 level, and reduce the number of autophagosomes in the hippocampus. Kumatakenin binds to Eno3 to upregulate its expression, reduce the stability and expression level of IRP1 mRNA, inhibit ferroptosis, alleviate intestinal inflammation, and restore epithelial barrier function. Kumatakenin enhances the efficacy of antibiotics against pathogenic bacteria, inhibits SARS-CoV-2 replication, and reduces cytokine production. Kumatakenin is applicable to research related to ovarian cancer, esophageal cancer, depression and colitis .
TRIM65 Human Pre-designed siRNA Set A
TRIM65 Human Pre-designed siRNA Set A
Cat. No.: HY-RS15065
Target:  

Small Interfering RNA (siRNA)

Research Areas:  

Others

TRIM65 Human Pre-designed siRNA Set A contains three designed siRNAs for TRIM65 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

Assay Types