TOM1L1 - target of myb1 like 1 membrane trafficking protein Gene

Also Known as SRCASM

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10040

About TOM1L1

Cytogenetic location: 17q22 Genomic coordinates (GRCh38): 17:54,900,852-54,961,956 (from NCBI)

This gene has 23 transcripts (splice variants), 152 orthologues and 10 paralogues. Broad expression in duodenum (RPKM 37.8), thyroid (RPKM 25.7) and 24 other tissues.

Summary

Enables clathrin binding activity and protein kinase binding activity. Involved in negative regulation of mitotic nuclear division; positive regulation of protein phosphorylation; and signal transduction. Located in cytosol and endosome. [provided by Alliance of Genome Resources, Apr 2022]

TOM1L1 Products (5)

mRNA Protein Name
NM_001321173.2 NP_001308102.1 TOM1-like protein 1 isoform 2
NM_001321174.2 NP_001308103.1 TOM1-like protein 1 isoform 3
NM_001321175.2 NP_001308104.1 TOM1-like protein 1 isoform 3
NM_001321176.2 NP_001308105.1 TOM1-like protein 1 isoform 3
NM_005486.3 NP_005477.2 TOM1-like protein 1 isoform 1

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables clathrin binding IDA
IDA: Inferred from direct assay
16412388 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
15611048 GOA
enables protein kinase binding IPI
IPI: Inferred from physical interaction
16479011 GOA
Biological Process GO Annotation Evidence References Source
involved in activation of protein kinase activity IDA
IDA: Inferred from direct assay
16479011 GOA
involved in negative regulation of mitotic nuclear division IDA
IDA: Inferred from direct assay
16479011 GOA
involved in positive regulation of protein autophosphorylation IDA
IDA: Inferred from direct assay
16479011 GOA
NOT involved in regulation of DNA biosynthetic process IDA
IDA: Inferred from direct assay
16479011 GOA
involved in signal transduction IDA
IDA: Inferred from direct assay
16479011 GOA
Cellular Component GO Annotation Evidence References Source
located in cytoplasm IDA
IDA: Inferred from direct assay
16412388 GOA
located in cytosol IDA
IDA: Inferred from direct assay
15611048 GOA
located in endosome IDA
IDA: Inferred from direct assay
15611048 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TOM1L1 Protein Structure

VHS

VHS: VHS domain (12 - 150)

GAT

GAT: GAT domain (199 - 292)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 476 a.a.
Protein Preferred Names Protein Names

TOM1-like protein 1

  • src-activating and signaling molecule protein

TOM1L1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TOM1L1 O75674 EGFR Homo sapiens P00533
Anti Bait CoIP
19798056
Intra
TOM1L1 O75674 VAV2 Homo sapiens P52735
Y2H
18654987
Intra
TOM1L1 O75674 CLTC Homo sapiens Q00610
Pull Down
19798056
Intra
TOM1L1 O75674 GRB2 Homo sapiens P62993
Pull Down
19798056
Intra
TOM1L1 O75674 GRB2 Homo sapiens P62993
Anti Bait CoIP
19798056
Intra
TOM1L1 O75674 TOM1 Homo sapiens O60784
Pull Down
19798056
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Nodular Basal Cell Carcinoma

  • Basal Cell Carcinoma, Nodular

  • Circumscribed Solid Basal Cell Carcinoma

  • Skin Nodulo-Ulcerative Basal Cell Carcinoma

  • Skin Solid Basal Cell Carcinoma

  • Skin Nodular Basal Cell Carcinoma

  • Skin Nodular Solid Basal Cell Carcinoma

  • Nodulo-Ulcerative Basal Cell Carcinoma

  • Circumscribed Solid Basal Cell Carcinoma Of Skin
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14877 TOM1L1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus TOM1L1 VGNC VGNC:36218
Canis familiaris TOM1L1 VGNC VGNC:47708
Rattus norvegicus TOM1L1 RGD RGD:1562626
Mus musculus TOM1L1 MGD MGI:1919193
Felis catus TOM1L1 VGNC VGNC:97667
Macaca mulatta TOM1L1 VGNC VGNC:78616
Others TOM1L1 NCBI