GP1BA - glycoprotein Ib platelet subunit alpha Gene
Also Known as BSS; GP1B; VWDP; CD42B; GPIbA; BDPLT1; BDPLT3; DBPLT3; GPIbalpha; CD42b-alpha
Species: Homo sapiens
About GP1BA
This gene has 1 transcript (splice variant), 99 orthologues, 22 paralogues and is associated with 8 phenotypes. Biased expression in lymph node (RPKM 7.8), spleen (RPKM 2.5) and 9 other tissues.
Summary
Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy. [provided by RefSeq, Oct 2013]
GP1BA Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_000173.7 | NP_000164.5 | platelet glycoprotein Ib alpha chain precursor |
| Molecular Function GO Annotation | Evidence | References | Source |
|---|---|---|---|
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
7721887 | GOA |
| Biological Process GO Annotation | Evidence | References | Source |
|---|---|---|---|
| acts upstream of or within blood coagulation |
IMP
IMP: Inferred from mutant phenotype
|
21037087 | GOA |
| involved in blood coagulation, intrinsic pathway |
IPI
IPI: Inferred from physical interaction
|
10501658 | GOA |
| acts upstream of or within cell adhesion |
IDA
IDA: Inferred from direct assay
|
9410473 | GOA |
| involved in fibrinolysis |
IDA
IDA: Inferred from direct assay
|
12855810 | GOA |
| involved in positive regulation of platelet activation |
IDA
IDA: Inferred from direct assay
|
1939645 | GOA |
| involved in release of sequestered calcium ion into cytosol |
IDA
IDA: Inferred from direct assay
|
1939645 | GOA |
| Cellular Component GO Annotation | Evidence | References | Source |
|---|---|---|---|
| colocalizes with external side of plasma membrane |
IDA
IDA: Inferred from direct assay
|
19443707 | GOA |
| part of glycoprotein Ib-IX-V complex |
IPI
IPI: Inferred from physical interaction
|
1730602 | GOA |
| located in membrane |
IDA
IDA: Inferred from direct assay
|
15297306 | GOA |
| located in plasma membrane |
IDA
IDA: Inferred from direct assay
|
15297306 | GOA |
GP1BA Protein Structure
LRRNT: Leucine rich repeat N-terminal domain (19 - 46)
(71 - 86)
LRR_1: Leucine Rich Repeat (97 - 110)
LRR_8: Leucine rich repeat (116 - 176)
- 0
- 100
- 200
- 300
- 400
- 500
- 600
- 652 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
platelet glycoprotein Ib alpha chain |
|
GP1BA Protein-protein interaction Information
|
Type
|
Protein Name | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | References |
|---|---|---|---|---|---|---|---|
|
Intra
|
GP1BA | P07359 | GP1BB | Homo sapiens | P13224 | 18674540 | |
|
Intra
|
GP1BA | P07359 | GP1BB | Homo sapiens | P13224 | 18674540 | |
|
Intra
|
GP1BA | P07359 | GP1BB | Homo sapiens | P13224 | 18789323 | |
|
Intra
|
GP1BA | P07359 | VWF | Homo sapiens | P04275 | 12183630 |
Recombinant GP1BA Proteins
| Cat. No. | Product Name | Accession | Purity |
|---|---|---|---|
| HY-P77951 | CD42b/GP1BA Protein, Human (HEK293, His) | P07359 (H17-L531) | ≥ 95%, as determined by Bis-Tris PAGE. |
GP1BA Antibodies
| Cat. No. | Product Name | Application | Reactivity |
|---|---|---|---|
| HY-P80060 | CD42b Antibody (YA803) | IHC-P, FC | Human |
| HY-P83989 | CD42b Antibody (YA3686) | WB, FC, ELISA | Human |
| HY-P83989A | CD42b Antibody (YA3686)(PBS only) | WB, FC, ELISA | Human |
| HY-P85891 | CD42b Antibody (YA5583) | IHC-P, ICC/IF, ELISA | Human, Mouse, Rat |
Related Diseases
| Diseases | Alias | |
|---|---|---|
| Pseudo-Von Willebrand Disease |
|
|
| Bernard-Soulier Syndrome, Type A2, Autosomal Dominant |
|
|
| Bernard-Soulier Syndrome |
|
|
| Nonarteritic Anterior Ischemic Optic Neuropathy |
|
|
| Autosomal Dominant Macrothrombocytopenia |
|
|
| Fetal And Neonatal Alloimmune Thrombocytopenia |
|
|
| Thrombocytopenia |
|
|
| Arteritic Anterior Ischemic Optic Neuropathy |
|
|
| Thrombosis |
|
|
| Von Willebrand'S Disease |
|
|
| Blood Platelet Disease |
|
|
| Glanzmann Thrombasthenia 1 |
|
|
| Coronary Thrombosis |
|
|
| Thrombocytopenic Purpura, Autoimmune |
|
|
| Ischemia |
|
|
| Hemorrhagic Disease |
|
|
| Neuropathy |
|
|
| Bleeding Disorder, Platelet-Type, 11 |
|
|
| Purpura |
|
|
| Endocarditis |
|
|
| Von Willebrand Disease, Type 1 |
|
|
| Thrombasthenia |
|
|
| Acquired Thrombocytopenia |
|
|
| Von Willebrand Disease, Type 2 |
|
|
| Acquired Von Willebrand Syndrome |
|
|
| Hemophilia B |
|
|
| Von Willebrand Disease, Type 3 |
|
|
| Trimethoprim Allergy |
|
|
| Vascular Disease |
|
|
| Antiphospholipid Syndrome |
|
|
| Pulmonary Embolism |
|
|
| Erythroleukemia |
|
|
| Myeloproliferative Syndrome, Transient |
|
|
| Myh-9 Related Disease |
|
|
| Thrombocytopenia Due To Platelet Alloimmunization |
|
|
| Blood Coagulation Disease |
|
|
| Arteriosclerosis |
|
|
| Qualitative Platelet Defect |
|
|
| Meckel Syndrome, Type 6 |
|
|
| Polycythemia Vera |
|
|
| Carotid Artery Thrombosis |
|
|
| Infective Endocarditis |
|
|
| Myocardial Infarction |
|
|
| Thrombotic Thrombocytopenic Purpura |
|
|
| Childhood Acute Megakaryoblastic Leukemia |
|
|
| Acrokeratoderma, Hereditary Papulotranslucent |
|
|
| Primary Thrombocytopenia |
|
|
| Amegakaryocytic Thrombocytopenia, Congenital |
|
|
| Aplastic Anemia |
|
|
| Acute Megakaryocytic Leukemia |
|
|
| Jacobsen Syndrome |
|
|
| Diabetes Mellitus |
|
|
| Deficiency Anemia |
|
|
| Stroke, Ischemic |
|
|
| Essential Thrombocythemia |
|
|
| Myelodysplastic Syndrome |
|
|
Orthologs Information
| Species | Symbol | Source | ID |
|---|---|---|---|
| Macaca mulatta | GP1BA | VGNC | VGNC:73113 |
| Rattus norvegicus | GP1BA | RGD | RGD:1310239 |
| Mus musculus | GP1BA | MGD | MGI:1333744 |
| Felis catus | GP1BA | VGNC | VGNC:99070 |
| Bos taurus | GP1BA | VGNC | VGNC:29504 |
| Others | GP1BA | NCBI |