7 Results for "

BC+cells

" in MedChemExpress (MCE) Product Catalog:
Products (7)

7 Results for "BC+cells" in MCE Product Catalog:

1
LMTK3-IN-1
LMTK3-IN-1
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1 Cited Publications
Cat. No.: HY-153896
CAS No.: 2764850-23-7
Pureté:  98.74%
Target:  

c-Met/HGFR

Domaines de recherche:  

Cancer

LMTK3-IN-1 (compound C28) is an ATP-competitive inhibitor of lemur tyrosine kinase 3 (LMTK3) (Kd=2.5 μM)，that acts by degrading LMTK3 via the ubiquitin-proteasome pathway. LMTK3-IN-1 shows anticancer activity in a variety of cancer cell lines and in vivo BC mouse models. LMTK3-IN-1 induces apoptosis in BC cell lines at 10-20 μM .
PROTAC ERα Degrader-4
PROTAC ERα Degrader-4
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Cat. No.: HY-149295
CAS No.: 2521299-80-7
Pureté:  98.63%
Target:  

PROTACs Estrogen Receptor/ERR Apoptosis

Domaines de recherche:  

Cancer

PROTAC ERα Degrader-4 (Compound ZD12) is a highly potent and selectivePROTAC ERα degrader (Ki: 5.08 μM). PROTAC ERα Degrader-4 contains OBHSAs, linker and E3 ligase ligands. PROTAC ERα Degrader-4 shows excellent cell inhibitory and ERα degradation activity against Tamoxifen-sensitive and -resistant ER + breast cancer (BC) cells and ERα-mutated BC cells. PROTAC ERα Degrader-4 can induce apoptosis and can be used for cancer research.
PROTAC AR Degrader-12
PROTAC AR Degrader-12
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Cat. No.: HY-179433
Target:  

PROTACs Androgen Receptor Estrogen Receptor/ERR Src

Domaines de recherche:  

Cancer

PROTAC AR Degrader-12 is a highly efficient PROTAC targeting AR coactivator binding site (AR-CBS). PROTAC AR Degrader-12 induces AR degradation in a ubiquitin proteasome system (UPS) pathway-dependent manner. PROTAC AR Degrader-12 inhibits tumor cell growth by affecting DNA replication and cell division PROTAC AR Degrader-12 could not only effectively degrade AR, but also potently inhibit the proliferation of MCF-7 and multiple mutant or resistant BC cells. PROTAC AR Degrader-12 effectively blocked estrogen receptor α (ERα) signaling through a dual mechanism involving ERα protein downregulation and suppression of its transcriptional activity. PROTAC AR Degrader-12 significantly inhibits the mRNA expression of FOXA1, GREB1, SRC, and PELP1. PROTAC AR Degrader-12 can be used for the study of breast cancer .
27-Hydroxy oncosterone
27-Hydroxy oncosterone
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Cat. No.: HY-N15953
CAS No.: 3056013-53-4
Category:  

Lipid

Target:  

Drug Metabolite

27-Hydroxy oncosterone is a metabolite that inhibits breast cancer (BC) cell proliferation and blocks oncosterone and 27-Hydroxycholesterol (HY-N2371)-induced proliferation in BC cells .
BSO-07
BSO-07
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Cat. No.: HY-162886
Target:  

JNK Reactive Oxygen Species (ROS)

Domaines de recherche:  

Cancer

BSO-07 is a ROS/JNK activator with significant anticancer effects, having an IC50 value of 24.81 μM against human breast cancer (BC) cells. BSO-07 induces apoptosis (Apoptosis) and paraptosis by activating JNK and increasing ROS levels, including enhancing the expression of apoptosis-associated proteins such as PARP, Bax, phosphorylated p53, ATF4, and CHOP, while decreasing the levels of anti-apoptotic proteins like Bcl-2, Bcl-xL, and Survivin. BSO-07 holds promise for research in the field of breast cancer .
DPP
DPP
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Cat. No.: HY-155807
CAS No.: 2668267-47-6
Target:  

STAT JAK Apoptosis

Domaines de recherche:  

Cancer

DPP is a Platinum(IV) complex, bearing pterostilbene-derived axial ligand. DPP inhibit the JAK2-STAT3 pathway in breast cancer (BC) cells with antiproliferative activity, and activates caspase-3 and cleaved poly ADP-ribose polymerase to induces apoptosis. DPP promotes the maturation and antigen presentation of dendritic cells, and exhibits in vivo safety .
STAT3-IN-18
STAT3-IN-18
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Cat. No.: HY-155808
CAS No.: 2668267-41-0
Target:  

STAT JAK Apoptosis COX

Domaines de recherche:  

Cancer

STAT3-IN-18 (compound SPP) is a platinum (IV) complex with an axial ligand derived from sandalwood. STAT3-IN-18 inhibits the JAK2-STAT3 pathway in breast cancer (BC) cells, with anti-proliferative activity. STAT3-IN-18 activates caspase-3 and increases cleaved polyADP-ribose polymerase to induce apoptosis. STAT3-IN-18 promotes maturation and antigen presentation of dendritic cells and demonstrates safety in vivo.
Assay Types