2521299-80-7
Chemical Structure
PROTAC ERα Degrader-4
- CAS No.: 2521299-80-7
- Formula:C55H62F3N5O10S2
- Molecular Weight:1074.23
InChIKey: BVQHGFDIIGLBQA-QBITVHLTSA-N
SMILES: O=[S](N(C(C=C1)=CC=C1OCCCCCC(N[C@@H](C(C)(C)C)C(N(C[C@@H]2O)[C@@H](C2)C(N[C@H](C3=CC=C(C(SC=N4)=C4C)C=C3)C)=O)=O)=O)CC(F)(F)F)(C5[C@@H]6C(C(C=C7)=CC=C7O)=C(C(C=C8)=CC=C8O)[C@H](C5)O6)=O
Biological Activity: PROTAC ERα Degrader-4 (Compound ZD12) is a highly potent and selectivePROTAC ERα degrader (Ki: 5.08 μM). PROTAC ERα Degrader-4 contains OBHSAs, linker and E3 ligase ligands. PROTAC ERα Degrader-4 shows excellent cell inhibitory and ERα degradation activity against Tamoxifen-sensitive and -resistant ER+ breast cancer (BC) cells and ERα-mutated BC cells. PROTAC ERα Degrader-4 can induce apoptosis and can be used for cancer research.
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PROTAC ERα Degrader-4 | 98.63% | PROTAC ERα Degrader-4 (Compound ZD12) is a highly potent and selectivePROTAC ERα degrader (Ki: 5.08 μM). PROTAC ERα Degrader-4 contains OBHSAs, linker and E3 ligase ligands. PROTAC ERα Degrader-4 shows excellent cell inhibitory and ERα degradation activity against Tamoxifen-sensitive and -resistant ER+ breast cancer (BC) cells and ERα-mutated BC cells. PROTAC ERα Degrader-4 can induce apoptosis and can be used for cancer research. | ||||||||||||||||||||
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Keywords
