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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
6 Results for "
Peli1
" in MedChemExpress (MCE) Product Catalog:
Products (6)
6 Results for "Peli1" in MCE Product Catalog:
Target:
Research Areas:
PELI1-IN-1 (compound 3d) is a potent inhibitor of PELI1, E3 ubiquitin ligase. PELI1-IN-1 has anti-tumPELI1-IN-1, a Resveratrol (HY-16561) derivative, is an orally active PELI1 Inhibitor (Kd = 8.2 μM). PELI1-IN-1 markedly interrupts the interaction of PELI1 and SNAIL/SLUG, and inhibits the K63-polyubiquitization of SNAIL/SLUG by PELI1, subsequently downregulating the protein levels of epithelial-mesenchymal transition (EMT) effectors SNAIL/SLUG. PELI1-IN-1 significantly reduces the level of SNAIL, SLUG and Vimentin without affecting the PELI1 expression. PELI1-IN-1 targets the FHA domain of PELI1 and disrupts the interaction, leading to the anti-metastasis of TNBC cells in vitro and in vivo. PELI1-IN-1 shows no evident toxicity in vivo [1].
Cat. No.: HY-RS10320
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Research Areas:
PELI1 Human Pre-designed siRNA Set A contains three designed siRNAs for PELI1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS18832
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Research Areas:
Peli1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Peli1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-RS25324
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Research Areas:
Peli1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Peli1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.
Cat. No.: HY-P704006
Purity: ≥ 80%, as determined by reducing SDS-PAGE.
Synonyms: E3 ubiquitin-protein ligase pellino homolog 1; Peli1; PRISM
Cat. No.: HY-P75970
Purity: ≥ 85%, as determined by reducing SDS-PAGE.
Synonyms: E3 ubiquitin-protein ligase pellino homolog 1; Peli1; PRISM
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
