3034889-94-3
Chemical Structure
PELI1-IN-1
- CAS No.: 3034889-94-3
- Formula:C20H16O4
- Molecular Weight:320.34
InChIKey: YZMSGTAAJTUBNJ-SNAWJCMRSA-N
SMILES: OC1=CC(O)=CC(/C=C/C2=C(C=CC(C3=CC=CC(O)=C3)=C2)O)=C1
Biological Activity: PELI1-IN-1 (compound 3d) is a potent inhibitor of PELI1, E3 ubiquitin ligase. PELI1-IN-1 has anti-tumPELI1-IN-1, a Resveratrol (HY-16561) derivative, is an orally active PELI1 Inhibitor (Kd = 8.2 μM). PELI1-IN-1 markedly interrupts the interaction of PELI1 and SNAIL/SLUG, and inhibits the K63-polyubiquitization of SNAIL/SLUG by PELI1, subsequently downregulating the protein levels of epithelial-mesenchymal transition (EMT) effectors SNAIL/SLUG. PELI1-IN-1 significantly reduces the level of SNAIL, SLUG and Vimentin without affecting the PELI1 expression. PELI1-IN-1 targets the FHA domain of PELI1 and disrupts the interaction, leading to the anti-metastasis of TNBC cells in vitro and in vivo. PELI1-IN-1 shows no evident toxicity in vivo[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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PELI1-IN-1 | 98.02% | PELI1-IN-1 (compound 3d) is a potent inhibitor of PELI1, E3 ubiquitin ligase. PELI1-IN-1 has anti-tumPELI1-IN-1, a Resveratrol (HY-16561) derivative, is an orally active PELI1 Inhibitor (Kd = 8.2 μM). PELI1-IN-1 markedly interrupts the interaction of PELI1 and SNAIL/SLUG, and inhibits the K63-polyubiquitization of SNAIL/SLUG by PELI1, subsequently downregulating the protein levels of epithelial-mesenchymal transition (EMT) effectors SNAIL/SLUG. PELI1-IN-1 significantly reduces the level of SNAIL, SLUG and Vimentin without affecting the PELI1 expression. PELI1-IN-1 targets the FHA domain of PELI1 and disrupts the interaction, leading to the anti-metastasis of TNBC cells in vitro and in vivo. PELI1-IN-1 shows no evident toxicity in vivo. | ||||||||||||||||||||
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Similarity Score 0.75
HY-N1430Oxyresveratrol -
Similarity Score 0.72
HY-N9805trans-3,5,3′-Trihydroxystilbene -
Similarity Score 0.72
HY-126052Gnetol -
Similarity Score 0.71
HY-13518Piceatannol -
Similarity Score 0.69
HY-16561Acis-Resveratrol -
Similarity Score 0.69
HY-16561RResveratrol (Standard) -
Similarity Score 0.69
HY-16561S2(E/Z)-Resveratrol-13CN6 -
Similarity Score 0.69
![[1,1′:4′,1′′-Terphenyl]-3,4′′,5-triol Chemical Structure](//file.medchemexpress.com/product_pic/hy-120654.gif)
HY-120654[1,1′:4′,1′′-Terphenyl]-3,4′′,5-triol -
Similarity Score 0.68
HY-N2593Isorhapontigenin -
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![[1,1′:4′,1′′-Terphenyl]-3,4′′,5-triol Chemical Structure](http://file.medchemexpress.com/product_pic/hy-120654.gif)
