3 Results for "

c48+80

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "c48+80" in MCE Product Catalog:

5
Compound 48/80 trihydrochloride
Compound 48/80 trihydrochloride
0 Images
5 Cited Publications
製品番号: HY-130592
CAS 番号: 848035-21-2
純度:  99.95%
別名: C48/80 trihydrochloride
Target:  

Phospholipase

研究分野:  

Neurological Disease

Compound 48/80 trihydrochloride (C48/80 trihydrochloride) is a mixture of condensation products of N-methyl-p-methoxyphenethylamine with formaldehyde. Compound 48/80 trihydrochloride is also a histamine releaser and a mast cell degranulator. Compound 48/80 inhibits phosphatidylinositol-specific phospholipase C activity from human platelets .
1
Z-3578
Z-3578
0 Images
1 Cited Publications
製品番号: HY-172458
CAS 番号: 473687-20-6
Target:  

Mas-related G-protein-coupled Receptor (MRGPR) TNF Receptor

研究分野:  

Inflammation/Immunology

Z-3578 is an orally active small-molecule antagonist of MrgX2 with potent antipseudoallergic activity, exhibiting a KD value of 729 nM. Z-3578 effectively inhibits mast cell degranulation induced by substance P (SP) and C48/80, suppresses the release of β-hexosaminidase, significantly reduces the release of histamine and TNF-α, and decreases intracellular calcium flux. In a mouse pseudoallergy model, Z-3578 significantly alleviates paw swelling and dye extravasation, and reduces serum histamine levels. Z-3578 can be used for the study of pseudoallergic reactions .
XAT-13
XAT-13
0 Images
製品番号: HY-181891
CAS 番号: 3107904-58-2
Target:  

Mas-related G-protein-coupled Receptor (MRGPR) Calcium Channel Glycosidase

研究分野:  

Inflammation/Immunology

XAT-13 is an orally active antiallergic agent. XAT-13 binds to the active pocket of MRGPRX2, and inhibits C48/80-induced calcium influx and β-hexosaminidase release. XAT-13 can be used for the research of pseudo-allergic diseases .
Assay Types