5 Results for "

chromomycin

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "chromomycin" in MCE Product Catalog:

1
Chromomycin A3
Chromomycin A3
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1 Cited Publications
Cat. No.: HY-W040129
CAS No.: 7059-24-7
Category:  

Microorganisms

Target:  

DNA Alkylator/Crosslinker DNA/RNA Synthesis Apoptosis Caspase

Chromomycin A3 is an inhibitor that selectively binds to GC-rich DNA sequences. Chromomycin A3 targets the DNA minor groove after forming a dimer with Mg 2+. Chromomycin A3 inhibits DNA replication and transcription, blocks the binding of Sp1 transcription factor to target gene promoters, downregulates the expression of anti-apoptotic proteins such as FLIP, Mcl-1, and XIAP, and induces S-phase cycle arrest and caspase-dependent apoptosis in tumor cells. Chromomycin A3 can antagonize oxidative stress induced by glutathione depletion and neuronal apoptosis induced by Camptothecin (HY-15660). Chromomycin A3 can be used in basic research on malignant tumors such as cholangiocarcinoma, and is a potential chemosensitizer and GC-rich region probe .
Chromomycin A2
Chromomycin A2
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Cat. No.: HY-135533
CAS No.: 6992-70-7
Synonyms: Aburamycin A
Category:  

Natural Products Microorganisms

Target:  

Autophagy

Chromomycin A2 (Aburamycin A) has cytotoxicity and induces autophagy. Chromomycin A2 has anti-tumor activity and can be used in cancer research .
Chromomycin A3 (Standard)
Chromomycin A3 (Standard)
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Cat. No.: HY-W040129R
CAS No.: 7059-24-7
Category:  

Microorganisms

Target:  

Reference Standards Bacterial Fungal Apoptosis Antibiotic

Chromomycin A3 (Standard) is the analytical standard of Chromomycin A3 (HY-W040129). This product is intended for research and analytical applications. Chromomycin A3 is an inhibitor that selectively binds to GC-rich DNA sequences. Chromomycin A3 targets the DNA minor groove after forming a dimer with Mg 2+. Chromomycin A3 inhibits DNA replication and transcription, blocks the binding of Sp1 transcription factor to target gene promoters, downregulates the expression of anti-apoptotic proteins such as FLIP, Mcl-1, and XIAP, and induces S-phase cycle arrest and caspase-dependent apoptosis in tumor cells. Chromomycin A3 can antagonize oxidative stress induced by glutathione depletion and neuronal apoptosis induced by Camptothecin (HY-15660). Chromomycin A3 can be used in basic research on malignant tumors such as cholangiocarcinoma, and is a potential chemosensitizer and GC-rich region probe .
Chromomycin A4
Chromomycin A4
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Cat. No.: HY-N9666
CAS No.: 7198-11-0
Category:  

Microorganisms Antibiotics

Target:  

Antibiotic Bacterial

Chromomycin A4, a major byproduct of Chromomycin A3 (HY-W040129)'s manufacture, is an antibiotic produced by Streptomyces griseus No. 7. Chromomycin A4 exhibits cancerostatic and antitumor activity. Chromomycin A4 shows strong growth inhibition against Gram-positive bacteria and and activity against tuberculous bacilli. Chromomycin A4 can be used for the research of bacterial infection .
Chromomycin 02-3G
Chromomycin 02-3G
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Cat. No.: HY-N19704
CAS No.: 132243-20-0
Category:  

Natural Products Microorganisms

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