2 Results for "

eponemycin

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "eponemycin" in MCE Product Catalog:

Eponemycin
Eponemycin
0 Images
Cat. No.: HY-N14221
CAS No.: 126509-46-4
Category:  

Microorganisms Antibiotics Other Antibiotics

Target:  

Antibiotic DNA/RNA Synthesis

Eponemycin is an antibiotic that exhibits antitumor activity. Eponemycin exhibits cytotoxicity in cancer cells B16-F10, L1210, P388 and HCT-116 with IC50 of 0.0017, 0.01, 0.031 and 0.0097 µg/mL, respectively. Eponemycin inhibits the DNA synthesis in B16-F10 and Mitomycin C with IC50 of 0.1 µg/mL and 0.41 µg/mL .
Dihydroeponemycin
Dihydroeponemycin
0 Images
Cat. No.: HY-108553
CAS No.: 126463-64-7
Target:  

Proteasome Apoptosis

Research Areas:  

Cancer

Dihydroeponemycin, an analogue of the antitumor and antiangiogenic natural product eponemycin, selectively targets the 20S proteasome. Dihydroeponemycin covalently modifies a subset of catalytic proteasomal subunits, binding preferentially to the IFN-gamma-inducible subunits LMP2 and LMP7. Dihydroeponemycin-mediated proteasome inhibition induces a spindle-like cellular morphological change and apoptosis .
Assay Types