126463-64-7
Chemical Structure
Dihydroeponemycin
- CAS No.: 126463-64-7
- Formula:C20H36N2O6
- Molecular Weight:400.51
IUPAC Name: N-((S)-3-hydroxy-1-(((S)-1-((R)-2-(hydroxymethyl)oxiran-2-yl)-4-methyl-1-oxopentan-2-yl)amino)-1-oxopropan-2-yl)-6-methylheptanamide
InChIKey: IUDBVFIQSSOIDB-TWOQFEAHSA-N
SMILES: CC(C)CCCCC(N[C@@H](CO)C(N[C@@H](CC(C)C)C([C@]1(CO1)CO)=O)=O)=O
Biological Activity: Dihydroeponemycin, an analogue of the antitumor and antiangiogenic natural product eponemycin, selectively targets the 20S proteasome. Dihydroeponemycin covalently modifies a subset of catalytic proteasomal subunits, binding preferentially to the IFN-gamma-inducible subunits LMP2 and LMP7. Dihydroeponemycin-mediated proteasome inhibition induces a spindle-like cellular morphological change and apoptosis[1].
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Dihydroeponemycin | Dihydroeponemycin, an analogue of the antitumor and antiangiogenic natural product eponemycin, selectively targets the 20S proteasome. Dihydroeponemycin covalently modifies a subset of catalytic proteasomal subunits, binding preferentially to the IFN-gamma-inducible subunits LMP2 and LMP7. Dihydroeponemycin-mediated proteasome inhibition induces a spindle-like cellular morphological change and apoptosis. | |||||||||||||||||||||
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