6 Results for "

iron+death

" in MedChemExpress (MCE) Product Catalog:
Products (6)

6 Results for "iron+death" in MCE Product Catalog:

2
FSEN1
FSEN1
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2 Cited Publications
Cat. No.: HY-153629
CAS No.: 862808-01-3
Purity:  99.56%
Target:  

Ferroptosis

Research Areas:  

Cancer

FSEN1 is a potent and non-competitive FSP1 inhibitor with an IC50 value of 313 nM. FSEN1 triggers iron death in cancer cells by inhibiting FSP1. FSEN1 can be used in research of cancer .
RIP1 kinase inhibitor 5
RIP1 kinase inhibitor 5
0 Images
Cat. No.: HY-153435
CAS No.: 2428422-17-5
Target:  

RIP kinase Necroptosis

Research Areas:  

Cancer

RIP1 kinase inhibitor 5 (example 1) is a potent inhibitor of RIP1, which is used as a checkpoint kinase to control tumor immunity . RIP1 kinase inhibitor 5 is similar with SIR1-365 (compound 13), which inhibits necrosis and iron death activity .
Mem-C1C18
Mem-C1C18
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Cat. No.: HY-149028
Target:  

Fluorescent Dye

Research Areas:  

Others

Mem-C1C18 is a polarity-sensitive fluorescent probe with excellent plasma membrane anchoring, high brightness and a sensitive response to environmental polarity by altering the fluorescence lifetime. Mem-C1C18 can be used to quantify changes in the polarity of the plasma membrane during iron death .
Lepadin E
Lepadin E
0 Images
Cat. No.: HY-155851
CAS No.: 444914-19-6
Category:  

Alkaloids Animals Marine natural products Other marine organisms Quinoline Alkaloids

Target:  

Ferroptosis MDM-2/p53 Glutathione Peroxidase ACSL Family

Lepadin E is a significantly cytotoxic ferroptosis inducer that induces iron death through the classical p53-SLC7A11-GPX4 pathway. Lepadin E promoted p53 expression, decreases SLC7A11 and GPX4 levels, and leads to increased ROS and lipid peroxide production, and upregulated ACSL4 expression, thus causes cell death. Lepadin E has significant antitumor effect .
CA IX/GPX4-IN-1
CA IX/GPX4-IN-1
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Cat. No.: HY-178475
Target:  

Carbonic Anhydrase Glutathione Peroxidase Ferroptosis

Research Areas:  

Cancer

CA IX/GPX4-IN-1 (Compound 22abcb) is a dual targeted inhibitor of CA IX and GPX4 activity. CA IX/GPX4-IN-1 can effectively kill SUM159PT cells (IC50 = 416 nM) by inducing iron death under hypoxic conditions. CA IX/GPX4-IN-1 has an IC50 of 663 nM to CA IX in SUM159PT-CAIX-FL cells. CA IX/GPX4-IN-1 can significantly inhibit tumor growth and can be reversed by ferroptosis inhibitors. CA IX/GPX4-IN-1 can be used for research on breast cancer and other cancers .
SRS6-11
SRS6-11
0 Images
Cat. No.: HY-183232
Target:  

Necroptosis

Research Areas:  

Cancer

SRS6-11 is an iron death-independent necrotic cell death (Necrosis) inducer. SRS6-11 retains significant lethality in the presence of α-tocopherol (HY-W020044). SRS6-11 can be used in fibrosarcoma research .
Assay Types