2. Apoptosis
  3. RIP kinase Necroptosis
  4. RIP1 kinase inhibitor 5

RIP1 kinase inhibitor 5 (example 1) is a potent inhibitor of RIP1, which is used as a checkpoint kinase to control tumor immunity. RIP1 kinase inhibitor 5 is similar with SIR1-365 (compound 13), which inhibits necrosis and iron death activity.

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RIP1 kinase inhibitor 5

RIP1 kinase inhibitor 5 Chemical Structure

CAS No. : 2428422-17-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
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Based on 1 publication(s) in Google Scholar

RIP1 kinase inhibitor 5 Related Antibodies

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Description

RIP1 kinase inhibitor 5 (example 1) is a potent inhibitor of RIP1, which is used as a checkpoint kinase to control tumor immunity[1]. RIP1 kinase inhibitor 5 is similar with SIR1-365 (compound 13), which inhibits necrosis and iron death activity[2].

IC50 & Target

RIP1[1]
Molecular Weight

257.28

Formula

C13H17F2NO2
CAS No.
Appearance

Solid

SMILES

CCC(C)(C)C(N(CC1=CC(F)=CC(F)=C1)O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (388.68 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8868 mL 19.4341 mL 38.8682 mL
5 mM 0.7774 mL 3.8868 mL 7.7736 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8868 mL 19.4341 mL 38.8682 mL 97.1704 mL
5 mM 0.7774 mL 3.8868 mL 7.7736 mL 19.4341 mL
10 mM 0.3887 mL 1.9434 mL 3.8868 mL 9.7170 mL
15 mM 0.2591 mL 1.2956 mL 2.5912 mL 6.4780 mL
20 mM 0.1943 mL 0.9717 mL 1.9434 mL 4.8585 mL
25 mM 0.1555 mL 0.7774 mL 1.5547 mL 3.8868 mL
30 mM 0.1296 mL 0.6478 mL 1.2956 mL 3.2390 mL
40 mM 0.0972 mL 0.4859 mL 0.9717 mL 2.4293 mL
50 mM 0.0777 mL 0.3887 mL 0.7774 mL 1.9434 mL
60 mM 0.0648 mL 0.3239 mL 0.6478 mL 1.6195 mL
80 mM 0.0486 mL 0.2429 mL 0.4859 mL 1.2146 mL
100 mM 0.0389 mL 0.1943 mL 0.3887 mL 0.9717 mL
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RIP1 kinase inhibitor 5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RIP1 kinase inhibitor 52428422-17-5RIP kinaseNecroptosisReceptor-interacting protein kinasesRIPKRIP1necrosisiron death activityInhibitorinhibitorinhibit

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