Lepadin E

Cat. No.: HY-155851: Data Sheet Handling Instructions
FAQs
Technical Support

Lepadin E is a significantly cytotoxic ferroptosis inducer that induces iron death through the classical p53-SLC7A11-GPX4 pathway. Lepadin E promoted p53 expression, decreases SLC7A11 and GPX4 levels, and leads to increased ROS and lipid peroxide production, and upregulated ACSL4 expression, thus causes cell death. Lepadin E has significant antitumor effect.

For research use only. We do not sell to patients.

Lepadin E Chemical Structure

CAS No. : 444914-19-6

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All ACSL Family Isoform Specific Products:

View All Isoforms

ACSL4 ACSL5

View All Glutathione Peroxidase Isoform Specific Products:

View All Isoforms

GPX1 GPX4

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

ACSL4

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	5.93 μM Compound: Lepadin E	Cytotoxicity against human A549 cells incubated for 72 hrs by MTT assay Cytotoxicity against human A549 cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
HeLa	IC₅₀	2.67 μM Compound: Lepadin E	Cytotoxicity against human HeLa cells incubated for 72 hrs by MTT assay Cytotoxicity against human HeLa cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
HepG2	IC₅₀	6.2 μM Compound: Lepadin E	Cytotoxicity against human HepG2 cells incubated for 72 hrs by MTT assay Cytotoxicity against human HepG2 cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
L02	IC₅₀	18.72 μM Compound: Lepadin E	Cytotoxicity against human L02 cells incubated for 72 hrs by MTT assay Cytotoxicity against human L02 cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
MCF7	IC₅₀	5.95 μM Compound: Lepadin E	Cytotoxicity against human MCF7 cells incubated for 72 hrs by MTT assay Cytotoxicity against human MCF7 cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
MDA-MB-231	IC₅₀	8.04 μM Compound: Lepadin E	Cytotoxicity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay Cytotoxicity against human MDA-MB-231 cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
NCI-H1155	IC₅₀	7.88 μM Compound: Lepadin E	Cytotoxicity against human NCI-H1155 cells incubated for 72 hrs by MTT assay Cytotoxicity against human NCI-H1155 cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
NCI-H1355	IC₅₀	8.8 μM Compound: Lepadin E	Cytotoxicity against human NCI-H1355 cells incubated for 72 hrs by MTT assay Cytotoxicity against human NCI-H1355 cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
SH-SY5Y	IC₅₀	6.19 μM Compound: Lepadin E	Cytotoxicity against human SH-SY5Y cells incubated for 72 hrs by MTT assay Cytotoxicity against human SH-SY5Y cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
SK-OV-3	IC₅₀	7.94 μM Compound: Lepadin E	Cytotoxicity against human SK-OV-3 cells incubated for 72 hrs by MTT assay Cytotoxicity against human SK-OV-3 cells incubated for 72 hrs by MTT assay	[PMID: 37578947]
SMMC-7721	IC₅₀	3.93 μM Compound: Lepadin E	Cytotoxicity against human SMMC-7721 cells incubated for 72 hrs by MTT assay Cytotoxicity against human SMMC-7721 cells incubated for 72 hrs by MTT assay	[PMID: 37578947]

Molecular Weight

421.66

Formula

C₂₆H₄₇NO₃

CAS No.

444914-19-6

SMILES

CCC[C@H](CCCC[C@@H](CCC[C@@]12[H])[C@]2([H])C[C@H]([C@@H](N1)C)OC(/C=C/CCCCC)=O)O

Structure Classification

Initial Source

Animals

Tropical Marine Tunicate Didemnum sp.

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang W, et al. Marine Alkaloid Lepadins E and H Induce Ferroptosis for Cancer Chemotherapy. J Med Chem. 2023 Aug 24;66(16):11201-11215. [Content Brief]

Lepadin E Related Classifications

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lepadin E444914-19-6FerroptosisACSL FamilyGlutathione PeroxidaseMDM-2/p53Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Requested Quantity *

Applicant Name *

Salutation

Email Address *

Phone Number *

Department

Organization Name *

City

State

Country or Region *

Remarks

Product Name

Lot #

Applicant Name *

Email Address *

Phone Number

Department *