2 Results for "

iwr1e

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "iwr1e" in MCE Product Catalog:

62
IWR-1
IWR-1
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62 Cited Publications
Cat. No.: HY-12238
CAS No.: 1127442-82-3
Purity:  99.60%
Synonyms: endo-iwr 1; iwr-1-endo
Target:  

Organoid Wnt

연구분야:  

Inflammation/Immunology Cancer

IWR-1 (IWR-1-endo) is a tankyrase inhibitor targeting Wnt/β-catenin (IC50 = 180 nM). IWR-1 compromises critical steps of the canonical Wnt signaling, namely translocation of β-catenin to the nucleus and subsequent TCF/LEF activation and expression of Wnt/β-catenin downstream targets. IWR-1 promotes β-catenin phosphorylation by promoting stability of Axin-scaffolded destruction complexes. IWR-1 can be studied in research for anti-tumor purposes, and diseases such as osteosarcoma, colorectal cancer and psoriasis .
IWR-1 (GMP)
IWR-1 (GMP)
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Cat. No.: HY-12238G
CAS No.: 1127442-82-3
Synonyms: endo-iwr 1 (GMP); iwr-1-endo (GMP)
IWR-1 (IWR-1-endo) (GMP) is the IWR-1 (HY-12238) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. IWR-1 (IWR-1-endo) is a tankyrase inhibitor targeting Wnt/β-catenin (IC50 = 180 nM). IWR-1 compromises critical steps of the canonical Wnt signaling, namely translocation of β-catenin to the nucleus and subsequent TCF/LEF activation and expression of Wnt/β-catenin downstream targets. IWR-1 promotes β-catenin phosphorylation by promoting stability of Axin-scaffolded destruction complexes. IWR-1 can be studied in research for anti-tumor purposes, and diseases such as osteosarcoma, colorectal cancer and psoriasis .
Assay Types