5 Results for "

panaxadiol

" in MedChemExpress (MCE) Product Catalog:
Products (5)

5 Results for "panaxadiol" in MCE Product Catalog:

4
Panaxadiol
Panaxadiol
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4 Cited Publications
Cat. No.: HY-N0596
CAS No.: 19666-76-3
Synonyms: 20(R)-panaxadiol
Category:  

Panax ginseng C. A. Meyer Triterpenes Terpenoids Plants Disease Research Fields Araliaceae Cancer

Target:  

PD-1/PD-L1 HIF/HIF Prolyl-Hydroxylase STAT

Panaxadiol (20(R)-Panaxadiol) is an orally active HIF-1α/STAT3 inhibitor. Panaxadiol can suppress HIF-1α and STAT3 then lead to downregulation of programmed cell death-ligand 1 (PD-L1) expression. Panaxadiol shows anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities .
NSD2/H3K36me2 modulator-1
NSD2/H3K36me2 modulator-1
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Cat. No.: HY-179427
Target:  

Histone Methyltransferase Apoptosis Reactive Oxygen Species (ROS)

Research Areas:  

Cancer

NSD2/H3K36me2 modulator-1 is an orally active NSD2/H3K36me2 modulator. NSD2/H3K36me2 modulator-1 competitively binds to the SAM pocket of NSD2, potently inhibits NSD2 expression and suppresses H3K36me2 methylation. NSD2/H3K36me2 modulator-1 reverses epithelial-mesenchymal transition (EMT), inhibits cell migration, and induces G0/G1 phase arrest and apoptosis. NSD2/H3K36me2 modulator-1 induces decreased Mitochondrial membrane potential (MMP) and subsequent Reactive oxygen species (ROS) generation. NSD2/H3K36me2 modulator-1 can be used to research the NSD2-targeting epigenetic anticancer strategies for hepatocellular carcinoma (HCC) .
EGFR-IN-169
EGFR-IN-169
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Cat. No.: HY-175531
Target:  

EGFR Apoptosis Reactive Oxygen Species (ROS) CDK Bcl-2 Family

Research Areas:  

Cancer

EGFR-IN-169 is an epidermal growth factor (EGFR) (IC50 = 5.19 μM) inhibitor form panaxadiol. EGFR-IN-169 interferes with the migration and growth of colorectal cancer cells by inhibiting EGFR-mediated RalA/EMT pathway. EGFR-IN-169 shows an IC50 value of 4.46 μM and SI of 16.92 for HCT-116 cells. EGFR-IN-169 inhibits CDKs activity, induces G0/G1 cycle arrest and inhibits migration and invasion. EGFR-IN-169 reduces mitochondrial membrane potential and induces apoptosis and ROS production. EGFR-IN-169 can be used for the research of cancer, such as colorectal cancer .
Panaxadiol (Standard)
Panaxadiol (Standard)
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Cat. No.: HY-N0596R
CAS No.: 19666-76-3
Synonyms: 20(R)-panaxadiol (Standard)
Category:  

Panax ginseng C. A. Meyer Triterpenes Terpenoids Plants Araliaceae

Target:  

Reference Standards PD-1/PD-L1 HIF/HIF Prolyl-Hydroxylase STAT

Panaxadiol (Standard) is the analytical standard of Panaxadiol. This product is intended for research and analytical applications. Panaxadiol (20(R)-Panaxadiol) is an orally active HIF-1α/STAT3 inhibitor. Panaxadiol can suppress HIF-1α and STAT3 then lead to downregulation of programmed cell death-ligand 1 (PD-L1) expression. Panaxadiol shows anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities .
Ginsenoside Ra6
Ginsenoside Ra6
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Cat. No.: HY-N12015
CAS No.: 1346522-89-1
Synonyms: Ginsenoside IV
Category:  

Panax ginseng C. A. Meyer Tetracyclic Triterpenoids Terpenoids Plants Araliaceae

Target:  

Others

Ginsenoside Ra6 (Ginsenoside IV) is a panaxadiol-type ginsenoside that can be isolated from the roots of ginseng .
Assay Types