1. Immunology/Inflammation
    Metabolic Enzyme/Protease
    JAK/STAT Signaling
    Stem Cell/Wnt
  2. PD-1/PD-L1
    HIF/HIF Prolyl-Hydroxylase
    STAT
  3. Panaxadiol

Panaxadiol  (Synonyms: 20(R)-Panaxadiol)

Cat. No.: HY-N0596 Purity: ≥98.0%
COA Handling Instructions

Panaxadiol (20(R)-Panaxadiol) is an orally active HIF-1α/STAT3 inhibitor. Panaxadiol can suppress HIF-1α and STAT3 then lead to downregulation of programmed cell death-ligand 1 (PD-L1) expression. Panaxadiol shows anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities.

For research use only. We do not sell to patients.

Panaxadiol Chemical Structure

Panaxadiol Chemical Structure

CAS No. : 19666-76-3

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Solution
10 mM * 1 mL in DMSO USD 106 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 106 In-stock
Estimated Time of Arrival: December 31
Solid
5 mg USD 96 In-stock
Estimated Time of Arrival: December 31
10 mg USD 120 In-stock
Estimated Time of Arrival: December 31
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Description

Panaxadiol (20(R)-Panaxadiol) is an orally active HIF-1α/STAT3 inhibitor. Panaxadiol can suppress HIF-1α and STAT3 then lead to downregulation of programmed cell death-ligand 1 (PD-L1) expression. Panaxadiol shows anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities[1][2].

In Vitro

Panaxadiol (1-10 μM, 12 h) inhibits PD-L1 expression in human colon cancer cells[1].
Panaxadiol (1-10 μM, 12 h) inhibits the expression of PD-L1 by suppressing HIF-1α and STAT3 in HCT116 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[1]

Cell Line: HCT116, SW620 and HT-29 colon cancer cells
Concentration: 1, 3, and 10 μM
Incubation Time: 12 hours
Result: Decreased the expression of PD-L1 protein and mRNA in a dose-dependent manner.

Western Blot Analysis[1]

Cell Line: HCT116 cells
Concentration: 1, 3, and 10 μM
Incubation Time: 12 hours
Result: Inhibited hypoxia-induced nuclear accumulation of HIF-1α in a dose-dependent manner.
Inhibited STAT3 phosphorylation at Tyr705 in a dose-dependent manner under both normoxic and hypoxic conditions.
In Vivo

Panaxadiol (oral gavage; 10 or 30 mg/kg; once every 3 days; 30 d) inhibits the growth of HCT116 cells in a xenograft model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c athymic nude mice injected with HCT116 cells[1]
Dosage: 10 or 30 mg/kg
Administration: Oral gavage; 10 or 30 mg/kg; once every 3 days; 30 days
Result: Inhibited the protein levels of HIF-1α, p-STAT-3 (Tyr705), PD-L1 and VEGF in tumour tissues in a dose-dependent manner.
Molecular Weight

460.73

Formula

C30H52O3

CAS No.
SMILES
Structure Classification
Source
Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (217.05 mM; Need ultrasonic)

Ethanol : 20 mg/mL (43.41 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1705 mL 10.8523 mL 21.7047 mL
5 mM 0.4341 mL 2.1705 mL 4.3409 mL
10 mM 0.2170 mL 1.0852 mL 2.1705 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.5 mg/mL (5.43 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.5 mg/mL (5.43 mM); Clear solution

*All of the co-solvents are available by MCE.
Purity & Documentation

Purity: ≥98.0%

References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Panaxadiol
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