19666-76-3
19666-76-3
Chemical Structure
Panaxadiol
Synonym(s): 20(R)-Panaxadiol
- CAS No.: 19666-76-3
- Formula:C30H52O3
- Molecular Weight:460.73
IUPAC Name: (3S,5R,8R,9R,10R,12R,13R,14R,17S)-4,4,8,10,14-pentamethyl-17-((R)-2,6,6-trimethyltetrahydro-2H-pyran-2-yl)hexadecahydro-1H-cyclopenta[a]phenanthrene-3,12-diol
InChIKey: PVLHOJXLNBFHDX-XHJPDDKBSA-N
SMILES: C[C@@]1(CC[C@@H]2O)[C@](C[C@H]3O)([H])[C@](CC[C@@]1([H])C2(C)C)(C)[C@@]4(C)[C@@]3([H])[C@]([C@](CCC5)(C)OC5(C)C)([H])CC4
Biological Activity: Panaxadiol (20(R)-Panaxadiol) is an orally active HIF-1α/STAT3 inhibitor. Panaxadiol can suppress HIF-1α and STAT3 then lead to downregulation of programmed cell death-ligand 1 (PD-L1) expression. Panaxadiol shows anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities[1][2].
| Cat. No. | 상품명 | Purity | 제품 설명 | Pricing | |||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
|
Panaxadiol | 99.89% | Panaxadiol (20(R)-Panaxadiol) is an orally active HIF-1α/STAT3 inhibitor. Panaxadiol can suppress HIF-1α and STAT3 then lead to downregulation of programmed cell death-ligand 1 (PD-L1) expression. Panaxadiol shows anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Panaxadiol (Standard) | ≥98% | Panaxadiol (Standard) is the analytical standard of Panaxadiol. This product is intended for research and analytical applications. Panaxadiol (20(R)-Panaxadiol) is an orally active HIF-1α/STAT3 inhibitor. Panaxadiol can suppress HIF-1α and STAT3 then lead to downregulation of programmed cell death-ligand 1 (PD-L1) expression. Panaxadiol shows anticancer, cardioprotective, anti-arrhythmic, and antioxidative activities. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
AMPK/mTOR modulator-1 | AMPK/mTOR modulator-1, Ginsenoside derivative, is an orally active mTOR inhibitor and AMPK activator. AMPK/mTOR modulator-1 activates AMPK signaling with a Kd of 4.759 μM. AMPK/mTOR modulator-1 promotes M1-like tumor-associated macrophage polarization while suppressing M2-like polarization. AMPK/mTOR modulator-1 can enhance glycolysis. AMPK/mTOR modulator-1 significantly inhibits tumor progression and shows anti-inflammation activity. AMPK/mTOR modulator-1 can be used for the research of colorectal cancer. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Panaxatriol | 99.93% | Panaxatriol is an orally active dammarane-type tetracyclic triterpene sapogenin. Panaxatriol enhances the phosphorylation levels of Akt, insulin receptor and p70S6K in skeletal muscle. Panaxatriol reduces the mRNA expression level of Atrogin1 in skeletal muscle. Panaxatriol induces apoptosis, pre-G1 cell cycle arrest and increased intracellular ROS levels in prostate cancer cells, decreases mitochondrial membrane potential, inhibits cell migration and reduces colony formation. Panaxatriol can be used in research related to insulin resistance, myocardial ischemia/reperfusion injury and prostate cancer. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Pixinol | Pixinol, a natural glycoside, shows cytotoxicity against the human lung carcinoma GLC4 and adenocarcinoma COLO 320 cell lines (IC50=71 µM and 43 µM, respectively). | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
3-Epicabraleadiol | 3-Epicabraleadiol (Ocotillol II) is a Triterpenoids product that can be isolated from the roots of Tripterygium wilfordii Hook.f.. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
3-epi-Cabraleahydroxylactone | 3-epi-Cabraleahydroxylactone (compound 3) is a triterpenoid that can be found in Aglaia angustifolia Miq. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Betulatriterpene C | Betulatriterpene C is a dammarane triterpene found in the glandular trichome exudates of Ibicella lutea. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Monogynol A | Monogynol A is an AChE/BChE inhibitor found in the aerial parts of Salvia trichoclada Bentham. Monogynol A can be used for the research of alzheimer’s disease. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Cabraleadiol | Cabraleadiol (3-Epiocotillol II) is isolated from the MeOH extract of the bark of Aglaia crassinervia. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Cabraleahydroxylactone | Cabraleahydroxylactone is a dammarane triterpenoid with antimycobacterial activity against Mycobacterium tuberculosis. | |||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
|
|
Hopane-3β,22-diol | 99.39% | Hopane-3β,22-diol (compound 74) is a hopane isolated from A. mariesii. | ||||||||||||||||||||
|
loading...
/
|
|||||||||||||||||||||||
References
- [1]. Wang Z, et al. Panaxadiol inhibits programmed cell death-ligand 1 expression and tumour proliferation via hypoxia-inducible factor (HIF)-1α and STAT3 in human colon cancer cells. Pharmacol Res. 2020;155:104727. [Content Brief]
- [2]. Myong Hak Ri, et al. Development of natural products for anti-PD-1/PD-L1 immunotherapy against cancer. J Ethnopharmacol. 2021 Dec 5;281:114370. [Content Brief]
