TBC1D25 - TBC1 domain family member 25 Gene

Also Known as MG81; OATL1

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 4943

About TBC1D25

Cytogenetic location: Xp11.23 Genomic coordinates (GRCh38): X:48,539,714-48,562,609 (from NCBI)

This gene has 5 transcripts (splice variants), 197 orthologues and 45 paralogues. Ubiquitous expression in testis (RPKM 5.6), brain (RPKM 5.2) and 25 other tissues.

Summary

This gene encodes a protein with a TBC domain and functions as a Rab GTPase activating protein. The encoded protein is involved in the fusion of autophagosomes with endosomes and lysosomes. This gene was previously known as ornithine aminotransferase-like 1, but has no similarity to ornithine aminotransferase. [provided by RefSeq, Jan 2017]

TBC1D25 Products (5)

mRNA Protein Name
NM_001348262.2 NP_001335191.1 TBC1 domain family member 25 isoform a
NM_001348263.2 NP_001335192.1 TBC1 domain family member 25 isoform b
NM_001348264.2 NP_001335193.1 TBC1 domain family member 25 isoform d
NM_001348265.2 NP_001335194.1 TBC1 domain family member 25 isoform d
NM_002536.4 NP_002527.1 TBC1 domain family member 25 isoform c

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables GTPase activator activity IDA
IDA: Inferred from direct assay
21383079 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
21383079 GOA
Biological Process GO Annotation Evidence References Source
involved in regulation of autophagosome maturation IMP
IMP: Inferred from mutant phenotype
21383079 GOA
Cellular Component GO Annotation Evidence References Source
located in autophagosome IDA
IDA: Inferred from direct assay
21383079 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TBC1D25 Protein Structure

RabGAP-TBC

RabGAP-TBC: Rab-GTPase-TBC domain (232 - 431)

  • 0
  • 200
  • 400
  • 600
  • 688 a.a.
Protein Preferred Names Protein Names

TBC1 domain family member 25

  • 5SN3 snoRNA

TBC1D25 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
TBC1D25 Q3MII6 FAM9B Homo sapiens Q8IZU0
Validated Y2H
32296183
Intra
TBC1D25 Q3MII6 LGALS14 Homo sapiens Q8TCE9
Validated Y2H
32296183
Intra
TBC1D25 Q3MII6 TRIML2 Homo sapiens Q8N7C3
Validated Y2H
32296183
Intra
TBC1D25 Q3MII6 LMNTD2 Homo sapiens Q8IXW0
Validated Y2H
32296183
Intra
TBC1D25 Q3MII6 LARP1B Homo sapiens Q659C4-6
Validated Y2H
32296183
Intra
TBC1D25 Q3MII6 KCNIP1 Homo sapiens Q9NZI2-2
Validated Y2H
32296183
Intra
TBC1D25 Q3MII6 MAP1LC3C Homo sapiens Q9BXW4
Validated Y2H
32296183
Intra
TBC1D25 Q3MII6 RUSC1 Homo sapiens Q9BVN2
Validated Y2H
32296183
Intra
TBC1D25 Q3MII6 GABARAPL2 Homo sapiens P60520
Anti Tag CoIP
28514442
Intra
TBC1D25 Q3MII6 GABARAPL2 Homo sapiens P60520
Anti Tag CoIP
33961781
Intra
TBC1D25 Q3MII6 GABARAPL1 Homo sapiens Q9H0R8
Anti Tag CoIP
33961781
Intra
TBC1D25 Q3MII6 GABARAPL1 Homo sapiens Q9H0R8
Anti Tag CoIP
28514442
Intra
TBC1D25 Q3MII6 GABARAPL1 Homo sapiens Q9H0R8
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Oligospermia
Non-Syndromic X-Linked Intellectual Disability 9

  • Mrx44

  • Mrx9

  • X-Linked Mental Retardation 44
Spindle Cell Synovial Sarcoma

  • Synovial Sarcoma With Spindle Cell Components

  • Synovial Sarcoma, Monophasic Fibrous

  • Synovial Sarcoma, Spindle Cell
Aland Island Eye Disease

  • AIED

  • Forsius-Eriksson Type Ocular Albinism

  • Forsius-Eriksson Syndrome

  • Autoimmune Inner Ear Disease

  • Forsius Eriksson Type Ocular Albinism

  • Aland Islands Eye Disease

  • Aaland Island Eye Disease

  • Ocular Albinism, Type Ii
Renal Cell Carcinoma, Papillary, 1

  • Papillary Renal Cell Carcinoma

  • Hereditary Papillary Renal Cell Carcinoma

  • Papillary Renal Cell Carcinoma, Sporadic

  • Papillary Renal Cell Adenocarcinoma

  • RCCP

  • RCCP1

  • Renal Cell Carcinoma, Papillary

  • Renal Cell Carcinoma, Papillary, 1, Familial And Somatic

  • Chromophil Carcinoma Of Kidney

  • Papillary Kidney Carcinoma

  • Sporadic Papillary Renal Cell Carcinoma

  • Chromophil Renal Cell Carcinoma

  • Papillary Renal Carcinoma, Malignant -

  • Papillary Renal Cell Carcinoma, Bilateral -

  • Papillary Renal Cell Carcinoma, Familial -

  • Papillary Renal Cell Carcinoma, Multiple -

  • Papillary Renal Cell Carcinoma, Sporadic -

  • Renal Adenocarcinoma

  • Chromophil Rcc

  • Hprcc

  • Renal Cell Carcinoma Papillary

  • Chromophilic Renal Cell Carcinoma

  • Prcc

  • Carcinoma, Renal Cell, Papillary, Type 1

  • Type 1 Papillary Renal Cell Carcinoma

  • Renal Cell Carcinoma

  • Hereditary Papillary Renal Carcinoma
Non-Syndromic X-Linked Intellectual Disability

  • X-Linked Non-Syndromic Intellectual Disability

  • Non-Specific X-Linked Mental Retardation

  • X-Linked Non-Specific Intellectual Disability
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS14239 TBC1D25 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus TBC1D25 MGD MGI:2444862
Bos taurus TBC1D25 VGNC VGNC:35639
Felis catus TBC1D25 VGNC VGNC:68610
Canis familiaris TBC1D25 VGNC VGNC:47144
Macaca mulatta TBC1D25 VGNC VGNC:78265
Rattus norvegicus TBC1D25 RGD RGD:1559711
Others TBC1D25 NCBI