Axin2 - axin 2 Gene

Also Known as axil; axin-2

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 29134

Summary

Enables beta-catenin binding activity and protein kinase binding activity. Involved in several processes, including negative regulation of Wnt signaling pathway involved in dorsal/ventral axis specification; negative regulation of cell population proliferation; and positive regulation of protein kinase activity. Part of protein-containing complex. Human ortholog(s) of this gene implicated in colorectal Cancer and endometrial adenocarcinoma. Orthologous to human AXIN2 (axin 2). [provided by Alliance of Genome Resources, Apr 2022]

Axin2 Products (1)

mRNA Protein Name
NM_024355.1 NP_077331.1 axin-2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables beta-catenin binding IDA
IDA: Inferred from direct assay
9566905 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
9566905 RGD
Biological Process GO Annotation Evidence References Source
involved in cellular response to dexamethasone stimulus IEP
IEP: Inferred from expression pattern
23996200 RGD
involved in cellular response to organic cyclic compound IEP
IEP: Inferred from expression pattern
19464575 RGD
involved in dorsal/ventral axis specification IDA
IDA: Inferred from direct assay
9566905 RGD
involved in negative regulation of Wnt signaling pathway IDA
IDA: Inferred from direct assay
9566905 RGD
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
15572025 RGD
involved in positive regulation of fat cell differentiation IMP
IMP: Inferred from mutant phenotype
23996200 RGD
involved in positive regulation of protein kinase activity IDA
IDA: Inferred from direct assay
9566905 RGD
involved in response to steroid hormone IEP
IEP: Inferred from expression pattern
22152883 RGD
Cellular Component GO Annotation Evidence References Source
part of protein-containing complex IDA
IDA: Inferred from direct assay
9566905 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

axin-2

  • axin-like protein

  • axis inhibition protein 2

  • conductin

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-137849 RK-582 Inhibitor 98.05% Phase 1

Pre-clinical Phase

Bioactive Molecules (12)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-123851 MSC2504877 Inhibitor 99.25% Unkown
HY-163767 Antitumor agent-171 Inhibitor 98.48% Unkown
HY-112799 DK419 Inhibitor 99.86% Unkown
HY-146336 PARP1/2/TNKS1/2-IN-1 98.66% Unkown
HY-108516 TC-E 5001 Inhibitor / Unkown
HY-114943 TNKS-IN-1 Inhibitor 99.55% Unkown
HY-165503 AZ1366 Inhibitor / Unkown
HY-180449 AXIN2/β-catenin-IN-1 Inhibitor / Unkown
HY-181930 TNIK-IN-10 / Unkown
HY-RS01292 AXIN2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20863 Axin2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27378 Axin2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Bioactive MoleculesInhibitory Antibodies (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-P991311 GSK3178022 Inhibitor / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Axin2 NCBI NCBI:8313