SYT3 - synaptotagmin 3 Gene

Also Known as SytIII

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 84258

About SYT3

Cytogenetic location: 19q13.33 Genomic coordinates (GRCh38): 19:50,621,977-50,639,881 (from NCBI)

This gene has 6 transcripts (splice variants), 180 orthologues and 31 paralogues. Biased expression in brain (RPKM 3.3), testis (RPKM 0.5) and 3 other tissues.

Summary

Predicted to enable several functions, including phospholipid binding activity; protein dimerization activity; and syntaxin binding activity. Involved in positive regulation of dendrite extension. Located in endosome. [provided by Alliance of Genome Resources, Apr 2022]

SYT3 Products (3)

mRNA	Protein	Name
NM_001160328.2	NP_001153800.1	synaptotagmin-3
NM_001160329.2	NP_001153801.1	synaptotagmin-3
NM_032298.3	NP_115674.1	synaptotagmin-3

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	32296183	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in positive regulation of dendrite extension	IDA IDA: Inferred from direct assay	23999003	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SYT3 Protein Structure

C2

0
100
200
300
400
500
590 a.a.

Protein Preferred Names	Protein Names
synaptotagmin-3	synaptotagmin III

SYT3 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SYT3	Q9BQG1	KCNJ6	Homo sapiens	P48051	Y2H Array	32296183
Intra	SYT3	Q9BQG1	KCNJ6	Homo sapiens	P48051	Y2H Prey Pooling	32296183
Intra	SYT3	Q9BQG1	CTSD	Homo sapiens	P07339	Y2H Pooling	32814053
Intra	SYT3	Q9BQG1	CTSD	Homo sapiens	P07339	Validated Y2H	32814053
Intra	SYT3	Q9BQG1	CTSD	Homo sapiens	P07339	Y2H Array	32814053
Intra	SYT3	Q9BQG1	RNF11	Homo sapiens	Q9Y3C5	Y2H Pooling	32814053
Intra	SYT3	Q9BQG1	RNF11	Homo sapiens	Q9Y3C5	Validated Y2H	32814053
Intra	SYT3	Q9BQG1	RNF11	Homo sapiens	Q9Y3C5	Y2H Array	32814053
Intra	SYT3	Q9BQG1	NEFL	Homo sapiens	P07196	Y2H Pooling	32814053
Intra	SYT3	Q9BQG1	NEFL	Homo sapiens	P07196	Validated Y2H	32814053
Intra	SYT3	Q9BQG1	NEFL	Homo sapiens	P07196	Y2H Array	32814053
Intra	SYT3	Q9BQG1	MRM1	Homo sapiens	Q6IN84	Y2H Array	32296183
Intra	SYT3	Q9BQG1	MRM1	Homo sapiens	Q6IN84	Y2H Prey Pooling	32296183
Intra	SYT3	Q9BQG1	WFS1	Homo sapiens	O76024	Y2H Pooling	32814053
Intra	SYT3	Q9BQG1	WFS1	Homo sapiens	O76024	Validated Y2H	32814053
Intra	SYT3	Q9BQG1	WFS1	Homo sapiens	O76024	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Deafness, Autosomal Recessive 9	Auditory Neuropathy, Autosomal Recessive, 1 Neurosensory Nonsyndromic Recessive Deafness 9 DFNB9 Nsrd9 Autosomal Recessive Nonsyndromic Deafness 9 Autosomal Recessive Deafness 9 Nrsd9 AUNB1 Nonsyndromic Auditory Neuropathy Autosomal Recessive Nsran Deafness, Autosomal Recessive, 9 Deafness Neurosensory Autosomal Recessive 9 Non-Syndromic Neurosensory Deafness Autosomal Recessive Type 9 Non-Syndromic Recessive Hearing Loss 9 Deafness, Autosomal Recessive, Type 9 Auditory Neuropathy, Nonsyndromic Recessive
Autosomal Recessive Limb-Girdle Muscular Dystrophy Type 2b	Lgmd2b Lgmd3 Limb-Girdle Muscular Dystrophy Due To Dysferlin Deficiency Limb-Girdle Muscular Dystrophy Type 3 Muscular Dystrophy, Limb-Girdle, Type 2b
Autosomal Recessive Limb-Girdle Muscular Dystrophy	Muscular Dystrophy, Limb-Girdle, Autosomal Recessive

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P2259	TAT-GluA2 3Y	Inhibitor	99.93%	Unkown
HY-RS14115	SYT3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SYT3	RGD	RGD:3805
Canis familiaris	SYT3	VGNC	VGNC:47046
Mus musculus	SYT3	MGD	MGI:99665
Felis catus	SYT3	VGNC	VGNC:65899
Bos taurus	SYT3	VGNC	VGNC:35542
Others	SYT3	NCBI