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Art. -Nr.: HY-N16339

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8-Desmethyleleutherin

8-Desmethyleleutherin (Compound 2) is an antibacterial agent that can be extracted from the bulbs of Eleutherine americana. 8-Desmethyleleutherin has MIC values of both 62.5 µg/mL for S. aureus strains ATCC27664 and ATCC25923.

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CAS. Nr.: 808148-30-3
Formel: C₁₅H₁₄O₄
Molecular Weight:258.27

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

8-Desmethyleleutherin Chemical Structure

CAS. Nr.: 808148-30-3

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Biologische Aktivität
- Beschreibung
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Cellular Effect

Cell Line	Type	Value	Description	References
MDA-MB-231	EC₅₀	0.475 μM Compound: 35	Cytotoxicity against human MDA-MB-231 cells overexpressing NADPH-cytochrome P450 reductase after 5 days Cytotoxicity against human MDA-MB-231 cells overexpressing NADPH-cytochrome P450 reductase after 5 days	[PMID: 24436995]
MDA-MB-231	EC₅₀	1.361 μM Compound: 35	Cytotoxicity against human MDA-MB-231 cells overexpressing DT-diaphorase after 5 days Cytotoxicity against human MDA-MB-231 cells overexpressing DT-diaphorase after 5 days	[PMID: 24436995]
MDA-MB-231	EC₅₀	2.095 μM Compound: 35	Cytotoxicity against wild-type human MDA-MB-231 cells after 5 days Cytotoxicity against wild-type human MDA-MB-231 cells after 5 days	[PMID: 24436995]
MDA-MB-231	EC₅₀	359.15 μM Compound: 35	Cytotoxicity against wild-type human MDA-MB-231 cells treated for 4 hrs under anoxic condition followed by compound-washout incubated in drug-free media for 5 days under aerobic condition Cytotoxicity against wild-type human MDA-MB-231 cells treated for 4 hrs under anoxic condition followed by compound-washout incubated in drug-free media for 5 days under aerobic condition	[PMID: 24436995]
MDA-MB-231	EC₅₀	4.1 μM Compound: 35	Cytotoxicity against human MDA-MB-231 cells overexpressing NADPH-cytochrome P450 reductase treated for 4 hrs under aerobic condition followed by compound-washout incubated in drug-free media for 5 days under aerobic condition Cytotoxicity against human MDA-MB-231 cells overexpressing NADPH-cytochrome P450 reductase treated for 4 hrs under aerobic condition followed by compound-washout incubated in drug-free media for 5 days under aerobic condition	[PMID: 24436995]
MDA-MB-231	EC₅₀	41.85 μM Compound: 35	Cytotoxicity against wild-type human MDA-MB-231 cells treated for 4 hrs under aerobic condition followed by compound-washout incubated in drug-free media for 5 days under aerobic condition Cytotoxicity against wild-type human MDA-MB-231 cells treated for 4 hrs under aerobic condition followed by compound-washout incubated in drug-free media for 5 days under aerobic condition	[PMID: 24436995]
MDA-MB-231	EC₅₀	86.5 μM Compound: 35	Cytotoxicity against human MDA-MB-231 cells overexpressing NADPH-cytochrome P450 reductase treated for 4 hrs under anoxic condition followed by compound-washout incubated in drug-free media for 5 days under aerobic condition Cytotoxicity against human MDA-MB-231 cells overexpressing NADPH-cytochrome P450 reductase treated for 4 hrs under anoxic condition followed by compound-washout incubated in drug-free media for 5 days under aerobic condition	[PMID: 24436995]

Chemical Information

CAS. Nr. 808148-30-3
Molecular Weight 258.27
Formel C₁₅H₁₄O₄
SMILES

O=C1C2=C([C@H](O[C@H](C2)C)C)C(C3=C(O)C=CC=C31)=O
Structure Classification
- Quinones
- Naphthalene Quinones
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Mahabusarakam W, et al. Naphthoquinones, anthraquinones and naphthalene derivatives from the bulbs of Eleutherine americana. Planta Med. 2010 Mar;76(4):345-9. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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