Trpm2 - transient receptor potential cation channel, subfamily M, member 2 Gene

Also Known as Trpm2-predicted

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 294329

Summary

Predicted to enable calcium ion binding activity; metal ion transmembrane transporter activity; and mono-ADP-D-ribose binding activity. Involved in several processes, including calcium ion import across plasma membrane; estrous cycle; and positive regulation of Insulin secretion. Located in neuron projection; neuronal cell body; and plasma membrane. Biomarker of transient cerebral ischemia. Orthologous to human TRPM2 (transient receptor potential cation channel subfamily M member 2). [provided by Alliance of Genome Resources, Apr 2022]

Trpm2 Products (1)

mRNA Protein Name
NM_001011559.2 NP_001011559.2 transient receptor potential cation channel subfamily M member 2

Gene Ontology

  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence References Source
involved in calcium ion import across plasma membrane IMP
IMP: Inferred from mutant phenotype
16651700 RGD
involved in cellular response to hydrogen peroxide IDA
IDA: Inferred from direct assay
16651700 RGD
involved in estrous cycle IEP
IEP: Inferred from expression pattern
24577155 RGD
involved in positive regulation of cellular response to oxidative stress IMP
IMP: Inferred from mutant phenotype
16651700 RGD
involved in positive regulation of insulin secretion IMP
IMP: Inferred from mutant phenotype
16601673 RGD
Cellular Component GO Annotation Evidence References Source
located in neuronal cell body IDA
IDA: Inferred from direct assay
16651700 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

transient receptor potential cation channel subfamily M member 2

  • transient receptor potential melastatin family 2

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-149143 JNJ-28583113 Inhibitor 98.82% Unkown
HY-P5883 TAT-M2NX Inhibitor 99.55% Unkown
HY-141713 ZA10 Inhibitor / Unkown
HY-178393 TRPM2-IN-2 Inhibitor / Unkown
HY-181481 2'-Deoxyadenosine-5'-O-diphosphoribose sodium Agonist / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Trpm2 NCBI NCBI:7226