TRPM2 - transient receptor potential cation channel subfamily M member 2 Gene

Also Known as KNP3; EREG1; TRPC7; LTRPC2; NUDT9H; LTrpC-2; NUDT9L1

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 7226

About TRPM2

Cytogenetic location: 21q22.3 Genomic coordinates (GRCh38): 21:44,353,621-44,442,644 (from NCBI)

This gene has 7 transcripts (splice variants), 243 orthologues and 7 paralogues. Broad expression in bone marrow (RPKM 4.5), brain (RPKM 2.6) and 21 other tissues.

Summary

The protein encoded by this gene forms a tetrameric cation channel that is permeable to calcium, sodium, and potassium and is regulated by free intracellular ADP-ribose. The encoded protein is activated by oxidative stress and confers susceptibility to cell death. Alternative splicing results in multiple transcript variants encoding distinct protein isoforms. Additional transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2016]

TRPM2 Products (4)

mRNA	Protein	Name
NM_001320350.2	NP_001307279.2	transient receptor potential cation channel subfamily M member 2 isoform 2
NM_001320351.2	NP_001307280.2	transient receptor potential cation channel subfamily M member 2 isoform 3
NM_001320352.3	NP_001307281.1	transient receptor potential cation channel subfamily M member 2 isoform 4
NM_003307.4	NP_003298.2	transient receptor potential cation channel subfamily M member 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
NOT enables ADP-ribose diphosphatase activity	IDA IDA: Inferred from direct assay	30467180	GOA
enables calcium ion binding	IDA IDA: Inferred from direct assay	30467180	GOA
enables calcium ion binding	IMP IMP: Inferred from mutant phenotype	19171771	GOA
NOT enables hydrolase activity	IMP IMP: Inferred from mutant phenotype	27383051	GOA
enables intracellularly gated calcium channel activity	IMP IMP: Inferred from mutant phenotype	27068538	GOA
enables ligand-gated calcium channel activity	IDA IDA: Inferred from direct assay	19171771	GOA
enables mono-ADP-D-ribose binding	IDA IDA: Inferred from direct assay	30467180	GOA
enables monoatomic cation channel activity	IMP IMP: Inferred from mutant phenotype	27068538	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in calcium ion transmembrane import into cytosol	IMP IMP: Inferred from mutant phenotype	19171771	GOA
involved in calcium ion transmembrane transport	IDA IDA: Inferred from direct assay	25620041	GOA
involved in cellular response to calcium ion	IMP IMP: Inferred from mutant phenotype	19171771	GOA
involved in cellular response to hydrogen peroxide	IDA IDA: Inferred from direct assay	27068538	GOA
involved in protein homotetramerization	IDA IDA: Inferred from direct assay	30467180	GOA
involved in regulation of actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	27068538	GOA
involved in regulation of filopodium assembly	IMP IMP: Inferred from mutant phenotype	27068538	GOA
involved in release of sequestered calcium ion into cytosol	IMP IMP: Inferred from mutant phenotype	27068538	GOA
involved in response to purine-containing compound	IMP IMP: Inferred from mutant phenotype	19171771	GOA
involved in zinc ion transmembrane transport	IMP IMP: Inferred from mutant phenotype	27068538	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in lysosome	IDA IDA: Inferred from direct assay	27068538	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	27333281	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	19171771	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TRPM2 Protein Structure

Ion_trans

0
300
600
900
1200
1503 a.a.

Protein Preferred Names	Protein Names
transient receptor potential cation channel subfamily M member 2	estrogen-responsive element-associated gene 1 protein

Related Diseases

Diseases	Alias
Calcific Tendinitis	Calcific Tendinitis Nos

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-149143	JNJ-28583113	Inhibitor	98.82%	Unkown
HY-P5883	TAT-M2NX	Inhibitor	99.55%	Unkown
HY-141713	ZA10	Inhibitor	/	Unkown
HY-178393	TRPM2-IN-2	Inhibitor	/	Unkown
HY-181481	2'-Deoxyadenosine-5'-O-diphosphoribose sodium	Agonist	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	TRPM2	VGNC	VGNC:36389
Felis catus	TRPM2	VGNC	VGNC:66588
Macaca mulatta	TRPM2	VGNC	VGNC:78655
Mus musculus	TRPM2	MGD	MGI:1351901
Rattus norvegicus	TRPM2	RGD	RGD:1311889
Others	TRPM2	NCBI