SLC3A2 - solute carrier family 3 member 2 Gene

Also Known as 4F2; CD98; MDU1; 4F2HC; 4T2HC; NACAE; CD98HC

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 6520

About SLC3A2

Cytogenetic location: 11q12.3 Genomic coordinates (GRCh38): 11:62,856,109-62,888,860 (from NCBI)

This gene has 41 transcripts (splice variants), 275 orthologues and 7 paralogues. Ubiquitous expression in kidney (RPKM 68.6), bone marrow (RPKM 41.5) and 25 other tissues.

Summary

This gene is a member of the solute carrier family and encodes a cell surface, transmembrane protein. The protein exists as the heavy chain of a heterodimer, covalently bound through di-sulfide bonds to one of several possible light chains. The encoded transporter plays a role in regulation of intracellular calcium levels and transports L-type Amino acids. Alternatively spliced transcript variants, encoding different isoforms, have been characterized. [provided by RefSeq, Nov 2010]

SLC3A2 Products (4)

mRNA	Protein	Name
NM_001012662.3	NP_001012680.1	4F2 cell-surface antigen heavy chain isoform b
NM_001012664.3	NP_001012682.1	4F2 cell-surface antigen heavy chain isoform e
NM_001013251.3	NP_001013269.1	4F2 cell-surface antigen heavy chain isoform f
NM_002394.6	NP_002385.3	4F2 cell-surface antigen heavy chain isoform c

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables L-alanine transmembrane transporter activity	IGI IGI: Inferred from genetic interaction	10391915	GOA
enables L-leucine transmembrane transporter activity	IGI IGI: Inferred from genetic interaction	10391915	GOA
enables aromatic amino acid transmembrane transporter activity	IGI IGI: Inferred from genetic interaction	15589117	GOA
enables double-stranded RNA binding	IDA IDA: Inferred from direct assay	21266579	GOA
enables exogenous protein binding	IDA IDA: Inferred from direct assay	30341327	GOA
enables neutral L-amino acid secondary active transmembrane transporter activity	IDA IDA: Inferred from direct assay	33298890	GOA
enables neutral L-amino acid transmembrane transporter activity	IGI IGI: Inferred from genetic interaction	17197568	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	9878049	GOA
enables protein heterodimerization activity	IDA IDA: Inferred from direct assay	33298890	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in L-alanine import across plasma membrane	IGI IGI: Inferred from genetic interaction	10391915	GOA
involved in L-histidine transport	IDA IDA: Inferred from direct assay	9751058	GOA
involved in L-leucine import across plasma membrane	IGI IGI: Inferred from genetic interaction	10391915	GOA
involved in L-leucine transport	IDA IDA: Inferred from direct assay	9751058	GOA
involved in L-leucine transport	IMP IMP: Inferred from mutant phenotype	30341327	GOA
involved in isoleucine transport	IDA IDA: Inferred from direct assay	11311135	GOA
involved in methionine transport	IDA IDA: Inferred from direct assay	11557028	GOA
involved in phenylalanine transport	IDA IDA: Inferred from direct assay	9751058	GOA
involved in phenylalanine transport	IGI IGI: Inferred from genetic interaction	15589117	GOA
involved in proline transport	IDA IDA: Inferred from direct assay	10574970	GOA
acts upstream of or within response to exogenous dsRNA	IMP IMP: Inferred from mutant phenotype	21266579	GOA
involved in symbiont entry into host cell	IMP IMP: Inferred from mutant phenotype	30341327	GOA
involved in thyroid hormone transport	IDA IDA: Inferred from direct assay	11564694	GOA
involved in tryptophan transport	IDA IDA: Inferred from direct assay	10574970	GOA
involved in tyrosine transport	IDA IDA: Inferred from direct assay	11557028	GOA
involved in valine transport	IDA IDA: Inferred from direct assay	11557028	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of amino acid transport complex	IDA IDA: Inferred from direct assay	30867591	GOA
located in apical plasma membrane	IDA IDA: Inferred from direct assay	31791063	GOA
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	31791063	GOA
located in cell surface	IDA IDA: Inferred from direct assay	25063885	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	11311135	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC3A2 Protein Structure

Alpha-amylase

0
100
200
300
400
500
600
630 a.a.

Protein Preferred Names	Protein Names
4F2 cell-surface antigen heavy chain	CD98 heavy chain

SLC3A2 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Cross	SLC3A2	P08195	sepZ	Escherichia coli	O52302	Y2H	20374249
Cross	SLC3A2	P08195	sepZ	Escherichia coli	O52302	Confocal	20374249
Cross	SLC3A2	P08195	sepZ	Escherichia coli	O52302	Anti Tag CoIP	20374249
Intra	SLC3A2	P08195	GPR37	Homo sapiens	O15354	Ub Reconstruction	28298427
Intra	SLC3A2	P08195	SLC7A11	Homo sapiens	Q9UPY5	3D-EM	34880232
Intra	SLC3A2	P08195	SLC7A5	Homo sapiens	Q01650	3D-EM	30867591
Intra	SLC3A2	P08195	SLC7A5	Homo sapiens	Q01650	GMS	30867591

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant SLC3A2 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P75368	CD98 Protein, Human (HEK293, His)	P08195-1 (R206-A630)	≥ 95%, as determined by reducing SDS-PAGE.

SLC3A2 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P89798	CD98 Antibody (YA9142)	WB, ICC/IF, IF-Tissue, FC, IP	human

Related Diseases

Diseases	Alias
Lysinuric Protein Intolerance	LPI Dibasic Amino Aciduria Ii Hyperdibasic Aminoaciduria Dibasic Aminoaciduria 2 Dibasicamino Aciduria Ii Congenital Lysinuria Lpi - Lysinuric Protein Intolerance
Cystinuria	CSNU Cystinuria Type B Cystinuria Type A Cystinuria, Type I, Formerly Csnu1, Formerly Cystinuria, Type Ii, Formerly Cystinuria, Type Iii, Formerly Csnu3, Formerly Cystinuria, Type Non-I, Formerly Cystinuria-Lysinuria Cystinuria-Lysinuria Syndrome Csnu1 Csnu3 Cystinuria 1 Cystinuria Type A/B Cystinuria Type I Cystinuria Type Ii Cystinuria Type Iii Cystinuria Type Non-I Cystinuria, Type A/B Cystinuria Type 1 Cystinuria - Lysinuria Csnu - [Cystinuria] Cystine Disease
Hepatitis C Virus	Hepatitis C Virus, Susceptibility To Hepatitis C Virus Infection, Response To Therapy Of Hcv Hcv, Susceptibility To Hepatitis C Virus, Resistance To Hepatitis C Virus, Response To Therapy Of Resistance To Hepatitis C Virus
Choriocarcinoma	Chorioepithelioma
Hepatitis	Chronic Hepatitis Chronic Persistent Hepatitis Acute Hepatitis Hepatitis, Chronic Acute And Subacute Liver Necrosis Acute/Subac. Necrosis Of Liver Animal Hepatitis Hepatitis Chronic Hepatitis A Hepatitis, Animal Hepatitis Due To Toxoplasmosis Hepatitis In Toxoplasmosis Toxoplasmal Hepatitis Chronic Hepatitis, Unspecified Chronic Active Hepatitis Nec Other Specified Chronic Hepatitis Chronic Persistent Hepatitis Nec Chronic Lobular Hepatitis Nec
Null-Cell Leukemia	Null Cell Acute Lymphoblastic Leukemia Null Cell Acute Lymphoblastic Leukaemia Null-Cell Leukaemia
Colon Carcinoma In Situ	Carcinoma In Situ Of Colon Stage 0 Colonic Carcinoma Stage 0 Carcinoma Of Colon Intraepithelial Neoplasia Of Colon, High Grade Carcinoma In Situ Of Cecum Carcinoma In Situ Of Hepatic Flexure Carcinoma In Situ Of Ileocecal Valve Carcinoma In Situ Of Hepatic Flexure Of Colon
Intestine Carcinoma In Situ
Lung Pleomorphic Carcinoma
Hartnup Disorder	Hartnup Disease HND Neutral 1 Amino Acid Transport Defect Neutral Amino Acid Transport Defect Deficiency Of Tryptophan Oxygenase Hartnup'S Disease Aminoaciduria, Hartnup Type Disorder Of Neutral Amino Acid Transport
Akinetopsia
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS13242	SLC3A2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS16997	Slc3a2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23440	Slc3a2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Rattus norvegicus	SLC3A2	RGD	RGD:3073
Mus musculus	SLC3A2	MGD	MGI:96955
Macaca mulatta	SLC3A2	VGNC	VGNC:77463
Bos taurus	SLC3A2	VGNC	VGNC:34871
Canis familiaris	SLC3A2	VGNC	VGNC:46410
Felis catus	SLC3A2	VGNC	VGNC:65366
Others	SLC3A2	NCBI