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GPR37 - G protein-coupled receptor 37 Gene

Also Known as PAELR; EDNRBL; hET(B)R-LP

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 2861

About GPR37

Cytogenetic location: 7q31.33 Genomic coordinates (GRCh38): 7:124,743,885-124,765,792 (from NCBI)

This gene has 1 transcript (splice variant), 268 orthologues and 15 paralogues. Biased expression in brain (RPKM 26.2), testis (RPKM 10.2) and 4 other tissues.

Summary

This gene is a member of the G protein-coupled receptor family. The encoded protein contains seven transmembrane domains and is found in cell and endoplasmic reticulum membranes. G protein-coupled receptors are involved in translating outside signals into G protein mediated intracellular effects. This gene product interacts with Parkin and is involved in juvenile Parkinson disease. [provided by RefSeq, Oct 2012]

GPR37 Products (1)

mRNA	Protein	Name
NM_005302.5	NP_005293.1	prosaposin receptor GPR37 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables G protein-coupled peptide receptor activity	IDA IDA: Inferred from direct assay	23690594	GOA
enables Hsp70 protein binding	IPI IPI: Inferred from physical interaction	12150907	GOA
enables heat shock protein binding	IPI IPI: Inferred from physical interaction	12150907	GOA
enables neuropeptide binding	IPI IPI: Inferred from physical interaction	16443751	GOA
enables neuropeptide receptor activity	IDA IDA: Inferred from direct assay	16443751	GOA
enables peptide binding	IPI IPI: Inferred from physical interaction	23690594	GOA
enables prosaposin receptor activity	IDA IDA: Inferred from direct assay	23690594	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	14532270	GOA
enables ubiquitin protein ligase binding	IPI IPI: Inferred from physical interaction	11439185	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	23690594	GOA
involved in neuropeptide signaling pathway	IDA IDA: Inferred from direct assay	16443751	GOA
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	23690594	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cell surface	IDA IDA: Inferred from direct assay	16443751	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	16443751	GOA
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	17059562	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	11439185	GOA
part of receptor complex	IDA IDA: Inferred from direct assay	23382219	GOA
part of ubiquitin ligase complex	IDA IDA: Inferred from direct assay	12150907	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

GPR37 Protein Structure

7tm_1

0
100
200
300
400
500
613 a.a.

Protein Preferred Names	Protein Names
prosaposin receptor GPR37	ETBR-LP-1

GPR37 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	GPR37	O15354	CREB5	Homo sapiens	Q02930-3	Validated Y2H	32814053
Intra	GPR37	O15354	CREB5	Homo sapiens	Q02930-3	Y2H Pooling	32814053
Intra	GPR37	O15354	CREB5	Homo sapiens	Q02930-3	Y2H Array	32814053
Intra	GPR37	O15354	LCE2A	Homo sapiens	Q5TA79	Validated Y2H	32814053
Intra	GPR37	O15354	LCE2A	Homo sapiens	Q5TA79	Y2H Array	32814053
Intra	GPR37	O15354	LCE2A	Homo sapiens	Q5TA79	Y2H Pooling	32814053
Intra	GPR37	O15354	FABP7	Homo sapiens	O15540	Y2H Array	32814053
Intra	GPR37	O15354	FABP7	Homo sapiens	O15540	Y2H Pooling	32814053
Intra	GPR37	O15354	FABP7	Homo sapiens	O15540	Validated Y2H	32814053
Intra	GPR37	O15354	MSRB3	Homo sapiens	Q8IXL7-2	Y2H Pooling	32814053
Intra	GPR37	O15354	MSRB3	Homo sapiens	Q8IXL7-2	Validated Y2H	32814053
Intra	GPR37	O15354	MSRB3	Homo sapiens	Q8IXL7-2	Y2H Array	32814053
Intra	GPR37	O15354	YIF1B	Homo sapiens	Q5BJH7	Anti Tag CoIP	28298427
Intra	GPR37	O15354	SDC2	Homo sapiens	P34741	Validated Y2H	32814053
Intra	GPR37	O15354	SDC2	Homo sapiens	P34741	Y2H Pooling	32814053
Intra	GPR37	O15354	SDC2	Homo sapiens	P34741	Y2H Array	32814053
Intra	GPR37	O15354	FAM76B	Homo sapiens	Q5HYJ3-3	Y2H Pooling	32814053
Intra	GPR37	O15354	FAM76B	Homo sapiens	Q5HYJ3-3	Validated Y2H	32814053
Intra	GPR37	O15354	FAM76B	Homo sapiens	Q5HYJ3-3	Y2H Array	32814053
Intra	GPR37	O15354	TTYH1	Homo sapiens	Q9H313	Anti Bait CoIP	28298427
Intra	GPR37	O15354	TMUB2	Homo sapiens	Q71RG4-4	Y2H Array	32814053
Intra	GPR37	O15354	TMUB2	Homo sapiens	Q71RG4-4	Y2H Pooling	32814053
Intra	GPR37	O15354	TMUB2	Homo sapiens	Q71RG4-4	Validated Y2H	32814053
Intra	GPR37	O15354	q7l8t7_human	Homo sapiens	Q7L8T7	Y2H Pooling	32814053
Intra	GPR37	O15354	q7l8t7_human	Homo sapiens	Q7L8T7	Validated Y2H	32814053
Intra	GPR37	O15354	q7l8t7_human	Homo sapiens	Q7L8T7	Y2H Array	32814053
Intra	GPR37	O15354	PXN	Homo sapiens	Q7Z7K5	Validated Y2H	32814053
Intra	GPR37	O15354	PXN	Homo sapiens	Q7Z7K5	Y2H Array	32814053
Intra	GPR37	O15354	PXN	Homo sapiens	Q7Z7K5	Y2H Pooling	32814053
Intra	GPR37	O15354	ZFHX2	Homo sapiens	Q9C0A1	Y2H Pooling	32814053
Intra	GPR37	O15354	ZFHX2	Homo sapiens	Q9C0A1	Validated Y2H	32814053
Intra	GPR37	O15354	ZFHX2	Homo sapiens	Q9C0A1	Y2H Array	32814053
Intra	GPR37	O15354	YIF1A	Homo sapiens	O95070	Anti Tag CoIP	28298427
Intra	GPR37	O15354	ADORA2A	Homo sapiens	P29274	Anti Bait CoIP	28298427
Intra	GPR37	O15354	ADORA2A	Homo sapiens	P29274	Ub Reconstruction	28298427
Intra	GPR37	O15354	ADORA2A	Homo sapiens	P29274	Anti Tag CoIP	28298427
Intra	GPR37	O15354	SCAMP4	Homo sapiens	Q969E2	Y2H Array	32814053
Intra	GPR37	O15354	SCAMP4	Homo sapiens	Q969E2	Y2H Pooling	32814053
Intra	GPR37	O15354	SCAMP4	Homo sapiens	Q969E2	Validated Y2H	32814053
Intra	GPR37	O15354	TMEM161A	Homo sapiens	Q9NX61	Anti Tag CoIP	28298427
Intra	GPR37	O15354	NR1D2	Homo sapiens	Q14995	Validated Y2H	32814053
Intra	GPR37	O15354	NR1D2	Homo sapiens	Q14995	Y2H Array	32814053
Intra	GPR37	O15354	NR1D2	Homo sapiens	Q14995	Y2H Pooling	32814053
Intra	GPR37	O15354	HTR4	Homo sapiens	Q13639	Ub Reconstruction	28298427
Intra	GPR37	O15354	HTR4	Homo sapiens	Q13639	Imaging	28298427
Intra	GPR37	O15354	HTR4	Homo sapiens	Q13639	Anti Tag CoIP	28298427
Intra	GPR37	O15354	HTR4	Homo sapiens	Q13639	BRET	28298427
Intra	GPR37	O15354	SLC6A3	Homo sapiens	Q01959	Anti Bait CoIP	17519329
Intra	GPR37	O15354	SLC6A3	Homo sapiens	Q01959	Anti Tag CoIP	17519329
Intra	GPR37	O15354	SLC3A2	Homo sapiens	P08195	Anti Tag CoIP	28298427
Intra	GPR37	O15354	SLC3A2	Homo sapiens	P08195	Anti Bait CoIP	28298427
Intra	GPR37	O15354	GABBR1	Homo sapiens	Q9UBS5	Anti Bait CoIP	28298427
Intra	GPR37	O15354	YY1	Homo sapiens	P25490	Validated Y2H	32814053
Intra	GPR37	O15354	YY1	Homo sapiens	P25490	Y2H Pooling	32814053
Intra	GPR37	O15354	YY1	Homo sapiens	P25490	Y2H Array	32814053
Intra	GPR37	O15354	PUM1	Homo sapiens	Q14671	Y2H Pooling	32814053
Intra	GPR37	O15354	PUM1	Homo sapiens	Q14671	Validated Y2H	32814053
Intra	GPR37	O15354	PUM1	Homo sapiens	Q14671	Y2H Array	32814053

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant GPR37 Proteins

Cat. No.	Product Name	Accession	Purity
HY-P76376	GPR37 Protein, Human (HEK293, His)	NP_005293.1/O15354 (A27-M265)	≥ 95%, as determined by reducing SDS-PAGE.

GPR37 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P83206	GPR37 Antibody (YA2951)	WB	Rat
HY-P83206A	GPR37 Antibody (YA2951)(PBS only)	WB	Rat

Related Diseases

Diseases	Alias
Juvenile-Onset Parkinson'S Disease	Juvenile-Onset Parkinson Disease
Epilepsy, Familial Temporal Lobe, 6	ETL6 Familial Temporal Lobe Epilepsy 6
Parkinson Disease, Late-Onset	Parkinson Disease Parkinson'S Disease PD PARK Parkinson Disease, Susceptibility To Late Onset Parkinson'S Disease Late Onset Parkinson Disease Paralysis Agitans Primary Parkinsonism Idiopathic Parkinson Disease Parkinson'S Parkinson Disease, Late-Onset, Susceptibility To Parkinson Disease, Age Of Onset, Modifier Lewy Body Parkinson Disease Idiopathic Parkinson'S Disease Pd - [Parkinson Disease] Parkinson Disease Nos Parkinson, Nos Primary Parkinson Disease

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Clinical Phase
Pre-clinical Phase

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-P1342	Prosaptide Tx14(A)		99.73%	Phase 2

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P3840	Head activator neuropeptide	Activator	99.51%	Unkown
HY-P1342A	Prosaptide Tx14(A) TFA	Activator	99.81%	Unkown
HY-RS05709	GPR37 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05710	GPR37L1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17660	Gpr37 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24121	Gpr37 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	GPR37	VGNC	VGNC:80054
Mus musculus	GPR37	MGD	MGI:1313297
Macaca mulatta	GPR37	VGNC	VGNC:73135
Rattus norvegicus	GPR37	RGD	RGD:619848
Bos taurus	GPR37	VGNC	VGNC:29585
Canis familiaris	GPR37	VGNC	VGNC:41432
Others	GPR37	NCBI