SLC7A5 - solute carrier family 7 member 5 Gene

Also Known as E16; CD98; LAT1; 4F2LC; MPE16; D16S469E

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 8140

About SLC7A5

Cytogenetic location: 16q24.2 Genomic coordinates (GRCh38): 16:87,830,023-87,869,507 (from NCBI)

This gene has 3 transcripts (splice variants), 244 orthologues and 12 paralogues. Broad expression in testis (RPKM 35.6), bone marrow (RPKM 34.4) and 17 other tissues.

Summary

Enables L-leucine transmembrane transporter activity; L-tryptophan transmembrane transporter activity; and thyroid hormone transmembrane transporter activity. Involved in carboxylic acid transport; thyroid hormone transport; and xenobiotic transport. Located in cytosol; intracellular membrane-bounded organelle; and plasma membrane. Is integral component of membrane. Part of amino acid transport complex; apical plasma membrane; and microvillus membrane. [provided by Alliance of Genome Resources, Apr 2022]

SLC7A5 Products (1)

mRNA	Protein	Name
NM_003486.7	NP_003477.4	large neutral amino acids transporter small subunit 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables L-leucine transmembrane transporter activity	IDA IDA: Inferred from direct assay	19075510	GOA
enables L-leucine transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	24038088	GOA
enables L-tryptophan transmembrane transporter activity	IDA IDA: Inferred from direct assay	30867591	GOA
enables amino acid transmembrane transporter activity	IDA IDA: Inferred from direct assay	26305885	GOA
enables amino acid transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	23567998	GOA
enables antiporter activity	IDA IDA: Inferred from direct assay	11847106	GOA
enables aromatic amino acid transmembrane transporter activity	IGI IGI: Inferred from genetic interaction	15589117	GOA
enables neutral L-amino acid transmembrane transporter activity	IDA IDA: Inferred from direct assay	26305885	GOA
enables neutral L-amino acid transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	17197568	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	25998567	GOA
enables thyroid hormone transmembrane transporter activity	IDA IDA: Inferred from direct assay	26305885	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in L-histidine transport	IDA IDA: Inferred from direct assay	9751058	GOA
involved in L-leucine import across plasma membrane	IDA IDA: Inferred from direct assay	19075510	GOA
involved in L-leucine import across plasma membrane	IMP IMP: Inferred from mutant phenotype	17197568	GOA
involved in L-leucine transport	IDA IDA: Inferred from direct assay	9751058	GOA
involved in L-tryptophan transmembrane transport	IDA IDA: Inferred from direct assay	30867591	GOA
involved in alanine transport	IDA IDA: Inferred from direct assay	18262359	GOA
involved in amino acid import across plasma membrane	IDA IDA: Inferred from direct assay	26305885	GOA
involved in amino acid import across plasma membrane	IMP IMP: Inferred from mutant phenotype	23567998	GOA
involved in isoleucine transport	IDA IDA: Inferred from direct assay	11557028	GOA
involved in methionine transport	IDA IDA: Inferred from direct assay	11557028	GOA
acts upstream of negative regulation of gene expression	IMP IMP: Inferred from mutant phenotype	24038088	GOA
involved in neutral amino acid transport	IDA IDA: Inferred from direct assay	11847106	GOA
involved in phenylalanine transport	IDA IDA: Inferred from direct assay	9751058	GOA
involved in phenylalanine transport	IGI IGI: Inferred from genetic interaction	15589117	GOA
acts upstream of positive regulation of interleukin-17 production	IMP IMP: Inferred from mutant phenotype	24038088	GOA
acts upstream of positive regulation of interleukin-4 production	IMP IMP: Inferred from mutant phenotype	24038088	GOA
acts upstream of positive regulation of type II interferon production	IMP IMP: Inferred from mutant phenotype	24038088	GOA
involved in proline transport	IDA IDA: Inferred from direct assay	10574970	GOA
involved in thyroid hormone transport	IDA IDA: Inferred from direct assay	11564694	GOA
involved in tryptophan transport	IDA IDA: Inferred from direct assay	10049700	GOA
involved in tyrosine transport	IDA IDA: Inferred from direct assay	11557028	GOA
involved in valine transport	IDA IDA: Inferred from direct assay	11557028	GOA
involved in xenobiotic transport	IMP IMP: Inferred from mutant phenotype	23567998	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of amino acid transport complex	IDA IDA: Inferred from direct assay	30867591	GOA
located in apical plasma membrane	IDA IDA: Inferred from direct assay	11742812	GOA
located in membrane	IDA IDA: Inferred from direct assay	30867591	GOA
located in microvillus membrane	IDA IDA: Inferred from direct assay	26050671	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	9751058	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC7A5 Protein Structure

AA_permease_2

0
100
200
300
400
507 a.a.

Protein Preferred Names	Protein Names
large neutral amino acids transporter small subunit 1	4F2 light chain

SLC7A5 Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	SLC7A5	Q01650	SLC3A2	Homo sapiens	P08195-1	GMS	31160781
Intra	SLC7A5	Q01650	SLC3A2	Homo sapiens	P08195-1	3D-EM	31160781
Intra	SLC7A5	Q01650	SLC3A2	Homo sapiens	P08195-1	Comigration in SDS	31160781
Intra	SLC7A5	Q01650	SLC3A2	Homo sapiens	P08195	Anti Tag CoIP	35271311

Cross: Cross-species interaction Intra: Intraspecies interaction

SLC7A5 Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P81448	SLC7A5/LAT1 Antibody (YA1193)	IHC-P	Human
HY-P81448A	SLC7A5/LAT1 Antibody (YA1193)(PBS only)	IHC-P	Human

Related Diseases

Diseases	Alias
Lysinuric Protein Intolerance	LPI Dibasic Amino Aciduria Ii Hyperdibasic Aminoaciduria Dibasic Aminoaciduria 2 Dibasicamino Aciduria Ii Congenital Lysinuria Lpi - Lysinuric Protein Intolerance
Phenylketonuria	Phenylalanine Hydroxylase Deficiency PKU Pah Deficiency Folling Disease Maternal Phenylketonuria Phenylketonurias Oligophrenia Phenylpyruvica Hyperphenylalaninemia, Non-Pku Mild Folling'S Disease Phenylalaninemia Mild Phenylketonuria Mild Pku Variant Pku Variant Phenylketonuria Mpku Deficiency Disease, Phenylalanine Hydroxylase Phenylketonuria, Maternal Phenylalanine Hydroxylase Deficiency Disease Hyperphenylalaninemic Embryopathy Maternal Pku Maternal Hyperphenylalaninemia Phenylketonuric Embryopathy Hyperphenylalaninemia HPA Non-Phenylketonuria Hyperphenylalaninemia NON-PKU HPA Phenylketonuria Maternal Classical Phenylketonuria Hyperphenylalaninaemia Pku - [Phenylketonuria]
Maple Syrup Urine Disease	MSUD Bckd Deficiency Branched-Chain Ketoaciduria Branched-Chain Alpha-Keto Acid Dehydrogenase Deficiency Keto Acid Decarboxylase Deficiency Maple Syrup Urine Disease, Type Ii Branched Chain Ketoaciduria Classic Maple Syrup Urine Disease Intermittent Maple Syrup Urine Disease Maple Syrup Urine Disease, Type Ia Ketoacidaemia Bckdh Deficiency Branched-Chain 2-Ketoacid Dehydrogenase Deficiency Thiamine-Responsive Maple Syrup Urine Disease Intermediate Maple Syrup Urine Disease Maple Syrup Urine Disease Type 1a Maple Syrup Urine Disease Type 1b Maple Syrup Urine Disease Type 2 Maple Syrup Urine Disease, Type Ib Dihydrolipoamide Dehydrogenase Deficiency Branched-Chain Ketoacid Dehydrogenase Deficiency Maple Syrup Disease Ketoacidemia Classic Bckd Deficiency Classic Msud Classic Branched-Chain Alpha-Ketoacid Dehydrogenase Deficiency Classic Branched-Chain Ketoaciduria Thiamine-Responsive Bckd Deficiency Thiamine-Responsive Msud Thiamine-Responsive Branched-Chain Alpha-Ketoacid Dehydrogenase Deficiency Intermittent Bckd Deficiency Intermittent Msud Intermittent Branched-Chain Alpha-Ketoacid Dehydrogenase Deficiency Maple Syrup Urine Disease 1a MSUD1A Maple Syrup Urine Disease Type Ia Msud Type Ia Maple Syrup Urine Disease 1b MSUD1B Maple Syrup Urine Disease Type Ib Msud Type Ib Maple Syrup Urine Disease 2 MSUD2 Maple Syrup Urine Disease Type Ii Msud Type Ii Nadh Cytochrome B5 Reductase Deficiency Lactic Acidosis, Congenital Infantile, Due To Lad Deficiency Ketonemia Maple Syrup Urine Disease, Type 1b Ketoacid Decarboxylase Deficiency Oxoacid Decarboxylase Deficiency Branched Chain Ketoacid Dehydrogenase Deficiency Msud - [Maple-Syrup-Urine Disease] Ketoaminoacidaemia Bckd - [Branched-Chain Alpha-Ketoacid Dehydrogenase Deficiency] Maple-Syrup-Urine Disorder Maple-Syrup-Urine Syndrome
Extrahepatic Bile Duct Adenocarcinoma	Adenocarcinoma Of The Extrahepatic Bile Duct Adenocarcinoma Of Extrahepatic Bile Duct
Central Serous Chorioretinopathy	Central Serous Chorioretinopathy After Bone Marrow Transplantation Central Serous Choroidopathy Cscr Central Serous Retinopathy Central Serous Choroidoretinopathy
Pancreatic Cancer	Pancreatic Carcinoma Carcinoma Of Pancreas Familial Pancreatic Carcinoma Pancreatic Neoplasm Pancreatic Carcinoma, Familial Malignant Neoplasm Of Pancreas Pancreatic Acinar Carcinoma Pancreatic Tumor Familial Pancreatic Cancer Neoplasm Of The Pancreas Cancer Of The Pancreas Pancreatic Carcinoma, Somatic Pancreatic Cancer, Somatic Ca Body Of Pancreas Ca Head Of Pancreas Ca Tail Of Pancreas Malignant Neoplasm Of Body Of Pancreas Malignant Neoplasm Of Head Of Pancreas Malignant Neoplasm Of Tail Of Pancreas Pancreas Neoplasm Exocrine Cancer Exocrine Pancreas Carcinoma Hereditary Pancreatic Cancer Hereditary Pancreatic Carcinoma PNCA Pancreatic Cancer, Susceptibility To Carcinoma Of Head Of Pancreas Pancreatic Neoplasms Pancreatic Tumors Cancer, Pancreatic Cancer Of Pancreas Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Lip And Oral Cavity Cancer	Oral Cancer Lip And Oral Cavity Carcinoma Malignant Neoplasm Of Mouth
Hartnup Disorder	Hartnup Disease HND Neutral 1 Amino Acid Transport Defect Neutral Amino Acid Transport Defect Deficiency Of Tryptophan Oxygenase Hartnup'S Disease Aminoaciduria, Hartnup Type Disorder Of Neutral Amino Acid Transport
Autism Spectrum Disorder	Asd Autism Spectrum Disorders Autistic Continuum Pervasive Developmental Disorder Pervasive Development Disorder Autistic Behavior Autistic Disorder Autistic Autistic Disorder Of Childhood Onset Infantile Autism Childhood Autism Kanner Syndrome Pervasive Developmental Delay Nos Pervasive Developmental Disorder, Not Otherwise Specified
Cystinuria	CSNU Cystinuria Type B Cystinuria Type A Cystinuria, Type I, Formerly Csnu1, Formerly Cystinuria, Type Ii, Formerly Cystinuria, Type Iii, Formerly Csnu3, Formerly Cystinuria, Type Non-I, Formerly Cystinuria-Lysinuria Cystinuria-Lysinuria Syndrome Csnu1 Csnu3 Cystinuria 1 Cystinuria Type A/B Cystinuria Type I Cystinuria Type Ii Cystinuria Type Iii Cystinuria Type Non-I Cystinuria, Type A/B Cystinuria Type 1 Cystinuria - Lysinuria Csnu - [Cystinuria] Cystine Disease
Autism	Autistic Disorder Autism Susceptibility 1 Childhood Autism Autistic Disorder Of Childhood Onset Infantile Autism Kanner'S Syndrome Autistic

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-120139	KMH-233	Inhibitor	99.75%	Unkown
HY-133677	Mono(2-ethyl-5-hydroxyhexyl) phthalate		99.03%	Unkown
HY-RS13331	SLC7A5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17279	Slc7a5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W267524	H-Phe(3-CF3)-OH		/	Unkown
HY-183513	L-Ala-BPA	Substrate	/	Unkown
HY-158161	JN-170	Inhibitor	/	Unkown
HY-164401A	QBS10072S dihydrochloride		/	Unkown
HY-RS23734	Slc7a5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W772441	H-Phe(3-tBu)-OH hydrochloride		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	SLC7A5	MGD	MGI:1298205
Rattus norvegicus	SLC7A5	RGD	RGD:620639
Felis catus	SLC7A5	VGNC	VGNC:97632
Bos taurus	SLC7A5	VGNC	VGNC:52250
Canis familiaris	SLC7A5	VGNC	VGNC:53447
Macaca mulatta	SLC7A5	VGNC	VGNC:104750
Others	SLC7A5	NCBI