RAP1A - RAP1A, member of RAS oncogene family Gene

Also Known as RAP1; C21KG; G-22K; KREV1; KREV-1; SMGP21

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 5906

About RAP1A

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:111,542,009-111,716,691 (from NCBI)

This gene has 4 transcripts (splice variants), 110 orthologues and 35 paralogues. Ubiquitous expression in appendix (RPKM 12.2), esophagus (RPKM 11.3) and 25 other tissues.

Summary

This gene encodes a member of the Ras family of small GTPases. The encoded protein undergoes a change in conformational state and activity, depending on whether it is bound to GTP or GDP. This protein is activated by several types of guanine nucleotide exchange factors (GEFs), and inactivated by two groups of GTPase-activating proteins (GAPs). The activation status of the encoded protein is therefore affected by the balance of intracellular levels of GEFs and GAPs. The encoded protein regulates signaling pathways that affect cell proliferation and adhesion, and may play a role in tumor malignancy. Pseudogenes of this gene have been defined on chromosomes 14 and 17. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

RAP1A Products (6)

mRNA	Protein	Name
NM_001010935.3	NP_001010935.1	ras-related protein Rap-1A precursor
NM_001291896.3	NP_001278825.1	ras-related protein Rap-1A precursor
NM_001370216.2	NP_001357145.1	ras-related protein Rap-1A precursor
NM_001370217.2	NP_001357146.1	ras-related protein Rap-1A precursor
NM_001394066.1	NP_001380995.1	ras-related protein Rap-1A precursor
NM_002884.4	NP_002875.1	ras-related protein Rap-1A precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables protein binding	IPI IPI: Inferred from physical interaction	7791872	GOA
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	23209302	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in Rap protein signal transduction	IMP IMP: Inferred from mutant phenotype	21840392	GOA
involved in cellular response to cAMP	IDA IDA: Inferred from direct assay	21840392	GOA
involved in establishment of endothelial barrier	IMP IMP: Inferred from mutant phenotype	21840392	GOA
NOT involved in microvillus assembly	IMP IMP: Inferred from mutant phenotype	22797597	GOA
involved in protein localization to plasma membrane	IDA IDA: Inferred from direct assay	17916086	GOA
involved in regulation of cell junction assembly	IMP IMP: Inferred from mutant phenotype	21840392	GOA
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IDA IDA: Inferred from direct assay	12202034	GOA
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane	IMP IMP: Inferred from mutant phenotype	12202034	GOA

Cellular Component GO Annotation	Evidence	References	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	11359771	GOA
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	12202034	GOA
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	12202034	GOA
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	11359771	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

RAP1A Protein Structure

Ras

0
100
184 a.a.

Protein Preferred Names	Protein Names
ras-related protein Rap-1A	GTP-binding protein smg p21A

RAP1A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	RAP1A	P62834	RAF1	Homo sapiens	P04049	X-Ray Diffraction	8756332
Intra	RAP1A	P62834	RASSF5	Homo sapiens	Q8WWW0-2	Anti Tag CoIP	15569673
Intra	RAP1A	P62834	RASSF5	Homo sapiens	Q8WWW0-2	Pull Down	12845325
Intra	RAP1A	P62834	RASSF5	Homo sapiens	Q8WWW0-2	Y2H	12845325
Cross	RAP1A	P62834	Rassf5	Mus musculus	Q5EBH1	Anti Tag CoIP	12845325

Cross: Cross-species interaction Intra: Intraspecies interaction

RAP1A Antibodies

Cat. No.	Product Name	Application	Reactivity
HY-P87048	RAP1A + RAP1B Antibody (YA6741)	WB, FC	Human, Mouse

Related Diseases

Diseases	Alias
Immunodeficiency 54	Natural Killer Cell Deficiency, Familial Isolated Primary Immunodeficiency With Natural-Killer Cell Deficiency And Adrenal Insufficiency IMD54 Nkcd Natural Killer Cell And Glucocorticoid Deficiency With Dna Repair Defect Nkgcd Familial Isolated Natural Killer Cell Deficiency Primary Immunodeficiency Due To Mcm4 Deficiency
Tuberous Sclerosis	Tuberous Sclerosis Syndrome Bourneville'S Disease Epiloia Cerebral Sclerosis Tuberose Sclerosis Tuberous Sclerosis 1 Bourneville Disease Bourneville Phakomatosis Pringle'S Disease
Babesiosis	Babesiasis Infection By Babesia Piroplasmosis Human Babesiosis Babesia Parasite Infection Piroplasma Infection
Glanzmann Thrombasthenia 1	Glanzmann Thrombasthenia Thrombasthenia Of Glanzmann And Naegeli Glanzmann'S Thrombasthenia Bdplt2 Platelet Glycoprotein Iib-Iiia Deficiency Deficiency Of Platelet Fibrinogen Receptor GT1 Gt Platelet Fibrinogen Receptor Deficiency Glycoprotein Complex Iib-Iiia Deficiency Deficiency Of Glycoprotein Complex Iib-Iiia Glycoprotein Iib/Iiia Defect Glanzmann Thrombasthenia, Type A Thrombasthenia Bleeding Disorder, Platelet-Type, 2 Gp Iib-Iiia Complex Deficiency Deficiency Of Gp Iib-Iiia Complex Platelet-Type Bleeding Disorder 2 Thrombocytasthenia Deficiency Of Gp 2b 3a Complex Diacyclothrombopathia 2b 3a Glanzmann Thrombasthenia Type A Platelet Fibrinogen Receptor, Deficiency Of Platelet Glycoprotein 2b 3a Deficiency Glanzmann Disease Glanzmann-Naegeli Disorder Hereditary Hemorrhagic Thrombasthenia Hereditary Thrombasthenia Bleeding Disorder Platelet-Type 2
Cervical Non-Keratinizing Squamous Cell Carcinoma
Chronic Granulomatous Disease	Cgd Granulomatous Disease, Chronic Autosomal Recessive Chronic Granulomatous Disease X-Linked Chronic Granulomatous Disease Bridges-Good Syndrome Congenital Dysphagocytosis Quie Syndrome Chronic Septic Granulomatosis Chronic Granulomatous Disorder Granulomatous Disease Chronic Granulomatous Disease, Chronic, X-Linked
Cerebral Cavernous Malformations	Cerebral Cavernous Malformation Cavernous Malformations Of Cns And Retina Cerebral Cavernous Malformation 1 Cavernous Angiomatous Malformations Cerebral Capillary Malformations CCM Hyperkeratotic Cutaneous Capillary-Venous Malformations Associated With Cerebral Capillary Malformations Familial Cavernous Angioma Cavernous Angioma Familial Cerebral Cavernous Malformation Cerebral Cavernous Malformations 1 Cavernous Angioma, Familial Cam Cerebral Cavernous Malformations-1 Cavernoma Central Nervous System Cavernous Hemangioma Cerebral Cavernous Hemangioma Familial Cavernous Hemangioma Familial Cavernous Malformation Familial Cerebral Cavernous Angioma Intracerebral Cavernous Hemangioma CCM1 Cavernous Hemangioma Of The Brain Cerebral Cavernoma Cerebral Cavernous Malformations, Type 1 Hemangioma, Cavernous, Central Nervous System Hemangioma, Cavernous Angioma, Cavernous
Cavernous Hemangioma	Hemangioma, Cavernous Cavernoma Cavernous Haemangioma
Klippel-Trenaunay-Weber Syndrome	Klippel-Trenaunay Syndrome KTS Ktw Syndrome Angioosteohypertrophy Syndrome Angio-Osteohypertrophy Syndrome Klippel Trenaunay Syndrome Klippel-Trénaunay-Weber Syndrome Haemangiectatic Hypertrophy Weber-Klippel-Trenaunay Congenital Dysplastic Angiopathy Klippel-Trenaunay Disease Weber Klippel Trenaunay
Breast Cancer	Breast Carcinoma Male Breast Cancer Breast Cancer, Familial Malignant Neoplasm Of Breast Breast Cancer, Susceptibility To Breast Cancer, Early-Onset Malignant Tumor Of Breast Carcinoma Of Male Breast Breast Cancer, Invasive Ductal Breast Cancer, Protection Against Breast Cancer, Somatic Breast Cancer, Male Breast Cancer, Lobular, Somatic Breast Tumor Mammary Cancer Mammary Tumor Malignant Neoplasm Of Male Breast Mammary Carcinoma Male Breast Carcinoma Familial Cancer Of Breast Invasive Ductal Breast Carcinoma Breast Cancer Susceptibility Breast Cancer, Male, Susceptibility To Breast Cancer, Early-Onset, Susceptibility To Malignant Tumor Of The Breast Mammary Neoplasm Primary Breast Cancer Neoplasm Of Male Breast Carcinoma Of Breast Breast Cancer In Men Familial Breast Cancer Cancer Of Breast BC Breast Cancer Familial Breast Cancer Familial Male Breast Cancer, Familial Male Breast Male Carcinoma Breast Neoplasms Breast Neoplasms, Male Mammary Tumors Mammary Carcinomas Cancer, Breast Cancer, Breast, Susceptibility Invasive Breast Ductal Carcinoma Breast Neoplasm Susceptibility To Breast Cancer Mammary Neoplasms Animal Mammary Neoplasms Primary Malignant Neoplasm Of Breast Infiltrating Ductal Carcinoma Of Breast Infiltrating Duct Carcinoma Of Unspecified Site Infiltrating Ductular Carcinoma Of Unspecified Site Invasive Breast Carcinoma Of No Special Type Microinvasive Carcinoma Of Breast Carcinoma With Apocrine Differentiation
Kabuki Syndrome 1	Kabuki Syndrome Niikawa-Kuroki Syndrome Kabuki Make-Up Syndrome Kms KABUK1 Kabuki Make Up Syndrome Nks Kabuki Makeup Syndrome Kabuki Syndrome, Type 1
Osteoporosis	Postmenopausal Osteoporosis Osteoporosis, Postmenopausal Bone Mineral Density Quantitative Trait Locus Bmnd Osteoporosis, Involutional Osteoporosis, Susceptibility To Osteoporosis, Postmenopausal, Susceptibility Bone Mineral Density Variation Qtl, Osteoporosis OSTEOP Involutional Osteoporosis Senile Osteoporosis Osteoporosis Postmenopausal Bone Mineral Density, Quantitative Trait Locus Osteoporosis, Senile Idiopathic Osteoporosis Bone Rarefaction Nos Type 1 Osteoporosis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Approval
Pre-clinical Phase

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-16322	Minodronic acid		99.67%	Unkown

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15871	GGTI298 Trifluoroacetate	Inducer	99.87%	Unkown
HY-123242	FTI-2153	Inhibitor	99.77%	Unkown
HY-12369	GGTI-2133	Inhibitor	98.50%	Unkown
HY-115489A	GGTI-286 TFA	Inhibitor	/	Unkown
HY-115489	GGTI-286	Inhibitor	/	Unkown
HY-100876	GGTI298	Inducer	/	Unkown
HY-117935	GGTI-286 hydrochloride	Inhibitor	/	Unkown
HY-123242A	FTI-2153 TFA	Inhibitor	99.11%	Unkown
HY-RS16300	Rap1a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-120229	GGTI-2147	Inhibitor	/	Unkown
HY-12369A	GGTI-2133 TFA	Inhibitor	/	Unkown
HY-RS11652	RAP1A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-120271	GGTI-297	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Bos taurus	RAP1A	VGNC	VGNC:33715
Rattus norvegicus	RAP1A	RGD	RGD:1359694
Felis catus	RAP1A	VGNC	VGNC:80336
Macaca mulatta	RAP1A	VGNC	VGNC:76657
Mus musculus	RAP1A	MGD	MGI:97852
Canis familiaris	RAP1A	VGNC	VGNC:49954
Others	RAP1A	NCBI