GGTI-297
GGTI-297 is a geranylgeranyl transferase I (GGTase-1) inhibitor with IC50 values of 56 nM and 203 nM for GGTase-1 and fanesyl transferase (FTase), respectively. GGTI-297 inhibits the processing of the geranylgeranylated protein Rap1A without affecting the farnesylated protein H-Ras.
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- CAS No.: 181045-83-0
- Formule: C26H31N3O3S
- Masse moléculaire:465.61
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Nude mice injected (8 week old) with A-549 or Calu-1 cells[2]
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Dosage:70 mg/kg
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Administration:ip; once a day; for 5 weeks (A-549 cells) and 12 weeks (Calu-1)
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Result:Inhibited the growth in nude mice of A-549 and Calu-1 xenografts.
Chemical Information
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CAS No. 181045-83-0
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Masse moléculaire 465.61
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Formule C26H31N3O3S
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SMILES
CC(C)C[C@@H](C(O)=O)NC(C1=CC=C(NC[C@@H](N)CS)C=C1C2=C3C=CC=CC3=CC=C2)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
[1]. Y Qian, et al. Selective inhibition of type-I geranylgeranyltransferase in vitro and in whole cells by CAAL peptidomimetics. Bioorg Med Chem. 1998 Mar;6(3):293-9. [Content Brief]
[2]. J Sun, et al. Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts. Oncogene. 1998 Mar;16(11):1467-73. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
GGTI-297 Related Classifications
HY-120271 Related Classifications
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