ALKBH2 - alkB homolog 2, alpha-ketoglutarate dependent dioxygenase Gene

Also Known as ABH2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 121642

About ALKBH2

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:109,088,189-109,093,472 (from NCBI)

This gene has 8 transcripts (splice variants) and 196 orthologues. Ubiquitous expression in ovary (RPKM 6.9), endometrium (RPKM 5.8) and 25 other tissues.

Summary

The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]

ALKBH2 Products (5)

mRNA Protein Name
NM_001001655.3 NP_001001655.1 DNA oxidative demethylase ALKBH2 isoform 1
NM_001145374.2 NP_001138846.1 DNA oxidative demethylase ALKBH2 isoform 1
NM_001145375.2 NP_001138847.1 DNA oxidative demethylase ALKBH2 isoform 1
NM_001205179.2 NP_001192108.1 DNA oxidative demethylase ALKBH2 isoform 2
NM_001205180.2 NP_001192109.1 DNA oxidative demethylase ALKBH2 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables broad specificity oxidative DNA demethylase activity IDA
IDA: Inferred from direct assay
12486230 GOA
enables cytosine C-5 DNA demethylase activity IDA
IDA: Inferred from direct assay
18432238 GOA
enables ferrous iron binding IDA
IDA: Inferred from direct assay
18432238 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
19736315 GOA
enables rDNA binding IDA
IDA: Inferred from direct assay
23972994 GOA
Biological Process GO Annotation Evidence References Source
involved in DNA alkylation repair IDA
IDA: Inferred from direct assay
18432238 GOA
Cellular Component GO Annotation Evidence References Source
located in nucleolus IDA
IDA: Inferred from direct assay
23972994 GOA
located in nucleoplasm IDA
IDA: Inferred from direct assay
23972994 GOA
located in nucleus IDA
IDA: Inferred from direct assay
19736315 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

ALKBH2 Protein Structure

2OG-FeII_Oxy_2

2OG-FeII_Oxy_2: 2OG-Fe(II) oxygenase superfamily (74 - 254)

  • 0
  • 100
  • 200
  • 261 a.a.
Protein Preferred Names Protein Names

DNA oxidative demethylase ALKBH2

  • 2OG-Fe(II) oxy DC1

ALKBH2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
ALKBH2 Q6NS38 GOLGA2 Homo sapiens Q08379
Y2H Array
32296183
Intra
ALKBH2 Q6NS38 GOLGA2 Homo sapiens Q08379
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

ALKBH2 Antibodies

Cat. No. Product Name Application Reactivity
HY-P82302 ALKBH2 Antibody (YA2047) WB Human, Mouse, Rat
HY-P82302A ALKBH2 Antibody (YA2047)(PBS only) WB Human, Mouse, Rat

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-168708 AH2-14c 98.01% Unkown
HY-RS00604 ALKBH2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ALKBH2 VGNC VGNC:25833
Felis catus ALKBH2 VGNC VGNC:59750
Rattus norvegicus ALKBH2 RGD RGD:1306377
Mus musculus ALKBH2 MGD MGI:2141032
Canis familiaris ALKBH2 VGNC VGNC:37803
Others ALKBH2 NCBI