2. Gene
  3. ALKBH2 - alkB homolog 2, alpha-ketoglutarate dependent dioxygenase Gene

ALKBH2 - alkB homolog 2, alpha-ketoglutarate dependent dioxygenase Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Homo sapiens

Also known as ABH2

Gene ID: 121642 | Gene type: protein coding

About ALKBH2

Cytogenetic location: 12q24.11 Genomic coordinates (GRCh38): 12:109,088,189-109,093,472 (from NCBI)

This gene has 8 transcripts (splice variants) and 196 orthologues. Ubiquitous expression in ovary (RPKM 6.9), endometrium (RPKM 5.8) and 25 other tissues.

Summary

The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]

ALKBH2 Products(5)

mRNA Protein Name
NM_001001655.3 NP_001001655.1 DNA oxidative demethylase ALKBH2 isoform 1
NM_001145374.2 NP_001138846.1 DNA oxidative demethylase ALKBH2 isoform 1
NM_001145375.2 NP_001138847.1 DNA oxidative demethylase ALKBH2 isoform 1
NM_001205179.2 NP_001192108.1 DNA oxidative demethylase ALKBH2 isoform 2
NM_001205180.2 NP_001192109.1 DNA oxidative demethylase ALKBH2 isoform 2

ALKBH2 Protein Structure

2OG-FeII_Oxy_2

2OG-FeII_Oxy_2: 2OG-Fe(II) oxygenase superfamily (74 - 254)

  • 0
  • 100
  • 200
  • 261 a.a.
Protein Preferred Names Protein Names

DNA oxidative demethylase ALKBH2

2OG-Fe(II) oxy DC1

Related Agents

Pre-clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00604 ALKBH2 Human Pre-designed siRNA Set A / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus ALKBH2 VGNC VGNC:25833
Felis catus ALKBH2 VGNC VGNC:59750
Rattus norvegicus ALKBH2 RGD RGD:1306377
Mus musculus ALKBH2 MGD MGI:2141032
Canis familiaris ALKBH2 VGNC VGNC:37803