SLC15A2 - solute carrier family 15 member 2 Gene

Also Known as PEPT2

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 6565

About SLC15A2

Cytogenetic location: 3q13.33 Genomic coordinates (GRCh38): 3:121,894,401-121,944,188 (from NCBI)

This gene has 7 transcripts (splice variants), 212 orthologues and 4 paralogues. Biased expression in prostate (RPKM 19.8), brain (RPKM 10.1) and 13 other tissues.

Summary

The mammalian kidney expresses a proton-coupled peptide transporter that is responsible for the absorption of small peptides, as well as Beta-lactam Antibiotics and Other peptide-like drugs, from the tubular filtrate. This transporter, SLC15A2, belongs to the same gene family as SLC15A1 (MIM 600544), the proton-coupled peptide transporter found in the small intestine (Liu et al, 1995 [PubMed 7756356]).[supplied by OMIM, Feb 2011]

SLC15A2 Products (2)

mRNA Protein Name
NM_001145998.2 NP_001139470.1 solute carrier family 15 member 2 isoform b
NM_021082.4 NP_066568.3 solute carrier family 15 member 2 isoform a

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence References Source
enables dipeptide transmembrane transporter activity IDA
IDA: Inferred from direct assay
7756356 GOA
enables peptide:proton symporter activity IDA
IDA: Inferred from direct assay
7756356 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
16738539 GOA
Biological Process GO Annotation Evidence References Source
involved in antibacterial innate immune response IDA
IDA: Inferred from direct assay
20406817 GOA
involved in dipeptide import across plasma membrane IDA
IDA: Inferred from direct assay
7756356 GOA
Cellular Component GO Annotation Evidence References Source
is active in phagocytic vesicle membrane IDA
IDA: Inferred from direct assay
20406817 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SLC15A2 Protein Structure

PTR2

PTR2: POT family (111 - 491)

  • 0
  • 200
  • 400
  • 600
  • 729 a.a.
Protein Preferred Names Protein Names

solute carrier family 15 member 2

  • kidney H(+)/peptide cotransporter

SLC15A2 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method References
Intra
SLC15A2 Q16348 KPRP Homo sapiens Q5T749
Validated Y2H
32296183
Intra
SLC15A2 Q16348 ANKS1A Homo sapiens Q49AR9
Validated Y2H
32296183
Intra
SLC15A2 Q16348 KRTAP15-1 Homo sapiens Q3LI76
Validated Y2H
32296183
Intra
SLC15A2 Q16348 WWOX Homo sapiens Q9NZC7-5
Validated Y2H
32296183
Intra
SLC15A2 Q16348 SMARCC1 Homo sapiens Q92922
Validated Y2H
32296183
Intra
SLC15A2 Q16348 KRTAP26-1 Homo sapiens Q6PEX3
Validated Y2H
32296183
Intra
SLC15A2 Q16348 KLHL38 Homo sapiens Q2WGJ6
Validated Y2H
32296183
Intra
SLC15A2 Q16348 C11orf87 Homo sapiens Q6NUJ2
Validated Y2H
32296183
Intra
SLC15A2 Q16348 NTAQ1 Homo sapiens Q96HA8
Validated Y2H
32296183
Intra
SLC15A2 Q16348 ENKD1 Homo sapiens Q9H0I2
Validated Y2H
32296183
Intra
SLC15A2 Q16348 TENT5B Homo sapiens Q96A09
Validated Y2H
32296183
Intra
SLC15A2 Q16348 PLSCR4 Homo sapiens Q9NRQ2
Validated Y2H
32296183
Intra
SLC15A2 Q16348 CHRD Homo sapiens Q9H2X0
Validated Y2H
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases Alias
Coproporphyria, Hereditary

  • Hereditary Coproporphyria

  • Coproporphyria

  • Coproporphyrinogen Oxidase Deficiency

  • HCP

  • Cpo Deficiency

  • Cpox Deficiency

  • Cpx Deficiency

  • Hereditary Coproporphyria Porphyria

  • Cpro Deficiency

  • Coproporphyria Hereditary

  • Porphyria Hepatica Ii

  • Porphyria Hepatica Coproporphyria

  • Porphyria, Hereditary Coproporphyria

  • Harderoporphyria
Porphyria Cutanea Tarda

  • Hepatoerythropoietic Porphyria

  • HEP

  • Uroporphyrinogen Decarboxylase Deficiency

  • Pct

  • Pct, Type Ii

  • Porphyria, Hepatocutaneous Type

  • Urod Deficiency

  • Porphyria, Hepatoerythropoietic

  • Porphyria Cutanea Tarda, Susceptibility To

  • Familial Porphyria Cutanea Tarda

  • Porphyria Cutanea Tarda, Type Ii

  • Pct, 'Familial' Type

  • Porphyria, Hepatic

  • FPCT

  • Pct Type Ii

  • Porphyria Cutanea Tarda Type Ii

  • Porphyria Hepatocutaneous Type

  • Heterozygous Uroporphyrinogen Decarboxylase Deficiency

  • Urod - [Uroporphyrinogen Decarboxylase] Deficiency

  • Pct - [Porphyria Cutanea Tarda]
Variegate Porphyria

  • Porphyria Variegata

  • Protoporphyrinogen Oxidase Deficiency

  • VP

  • Ppox Deficiency

  • Porphyria, South African Type

  • Porphyria Variegata, Susceptibility To

  • Protocoproporphyria

  • Porphyria Variegate

  • Porphyria South African Type

  • Pv

  • Porphyria, Variegate

  • Vp - [Variegate Porphyria]
Porphyria, Acute Intermittent

  • Acute Intermittent Porphyria

  • Porphobilinogen Deaminase Deficiency

  • Pbgd Deficiency

  • AIP

  • Porphyria, Swedish Type

  • Uroporphyrinogen Synthase Deficiency

  • Ups Deficiency

  • Porphyria, Acute Intermittent, Nonerythroid Variant

  • Hydroxymethylbilane Synthase Deficiency

  • Aip - Acute Intermittent Porphyria

  • Porphyria Intermittent Acute

  • Pyrroloporphyria

  • Hmbs Deficiency

  • Porphyria Acute Intermittent
Hypotrichosis 4

  • HYPT4

  • Marie Unna Hereditary Hypotrichosis 1

  • Muhh1

  • Hypotrichosis, Marie Unna Type, 1

  • Hypotrichosis Marie Unna 1

  • Marie Unna Hereditary Hypotrichosis Type 1

  • Hypotrichosis, Hereditary, Marie Unna Type, 1

  • Hypotrichosis, Type 4
Acute Porphyria

  • Porphyrias, Hepatic

  • Hepatic Porphyria

  • Porphyria Hepatic

  • Acute Intermittent Porphyria
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
Cat. No. Product Name
Effect
Purity
Rare Diseases
HY-RS13013 SLC15A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus SLC15A2 VGNC VGNC:65201
Rattus norvegicus SLC15A2 RGD RGD:61972
Macaca mulatta SLC15A2 VGNC VGNC:77394
Canis familiaris SLC15A2 VGNC VGNC:46233
Mus musculus SLC15A2 MGD MGI:1890457
Others SLC15A2 NCBI