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Cat. No.: HY-186145

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WMK-1

WMK-1 is a 1,2,4,5-tetraoxane derivative and ferroptosis inducer, with significantly higher cytotoxicity against cancer cells than non-cancerous cells. WMK-1 triggers ferroptosis in cancer cells and cancer stem cells. WMK-1 can be used for the research of cancer.

For research use only. We do not sell to patients.

CAS No.: 2814563-83-0
Formula: C₃₅H₅₁IN₂O₆
Molecular Weight:722.69

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

WMK-1 Chemical Structure

CAS No.: 2814563-83-0

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- In Vitro
- In Vivo
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

In Vitro

WMK-1 (compound 48) (48 h) potently inhibits viability of MDA-MB-231, Hela, T47D, Jurkat, HCT116, and HL-60 cancer cells with IC₅₀ values ranging from 1.0 μM to 6.3 μM^[1].
WMK-1 (48 h) potently inhibits viability of HeyA8 ovarian cancer cells (IC₅₀ = 2.3 μM) and HeyA8sp ovarian cancer stem cell spheres (IC₅₀ = 1.2 μM)^[1].
WMK-1 (24 h) induces ferroptosis in HeyA8 ovarian cancer cells, HeyA8 ovarian cancer stem cells, and HeyA8 ovarian cancer stem cell spheres^[1].
WMK-1 (5 μM; 6 h) increases lipid reactive oxygen species levels in MDA-MB-231 triple negative breast cancer cells^[1].
WMK-1 (5 μM) induced cell death in MDA-MB-231 triple-negative breast cancer cells at indicated concentrations within 24 h, and this effect was significantly reversed by 30 μM liproxstatin-1 (HY-12726) pretreatment^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

WMK-1 (compound 48) (5-10 mg/kg, i.p.) reduced tumor burden in both ovarian cancer and triple-negative breast cancer xenograft models in nude mice, with no observable systemic or organ-related toxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Nude mice (female)^[1]
Dosage:

5 mg/kg; 10 mg/kg
Administration:

i.p.
Result:

Reduced ovarian cancer xenograft tumor size.
Caused no abnormal behavior or weight loss in treated animals during the entire study period.

Chemical Information

CAS No. 2814563-83-0
Molecular Weight 722.69
Formula C₃₅H₅₁IN₂O₆
SMILES

CC(C)(C)C1CCC2(OOC3(CCC(OC(NCCC[N+](CC4=CC=CC=C4)(C)CC5=CC=CC=C5)=O)CC3)OO2)CC1.[I-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Dan Yang, et al. Targeted delivery of 1, 2, 4, 5-tetraoxane compounds and their uses, WO, WO2022161490A1, 2022-08-04.

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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