AKR1B10-IN-1
Based on 1 Customer Validation
AKR1B10-IN-1 is a potent inhibitor of AKR1B10 (Aldo-Keto Reductase 1B10) with an IC50 of 3.5 nM. AKR1B10-IN-1 suppresses proliferation, metastasis, and Cisplatin (CDDP) resistance of lung cancer cells.
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- Pureté: 99.08%
- CAS No.: 2136579-33-2
- Formule: C19H16FNO4
- Masse moléculaire:341.33
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
3.5 nM (AKR1B10); 277 nM (AKR1B1)[1]
AKR1B10-IN-1 (compound 4e) (0-20 μM; 96 hours) dose-dependently suppresses the growth of both A549 and A549/1B10 cells[1].
AKR1B10-IN-1 (compound 4e) (0-20 μM; 96 hours) completely suppresses increased cell proliferation by the overexpressing AKR1B10 as well as the endogenous protein[1].
AKR1B10-IN-1 (compound 4e) (0-40 μM; 26 hours; pretreatment with AKR1B10-IN-1 for 2 hours, then incubated with CDDP for 24 hours) decreases the cell viability of CDDP-R-A549 cells in a dose-dependent manner[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549 cells, A549/1B10 cells (AKR1B10-stably overexpressing A549 cells)
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Concentration:0, 10, 20 μM
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Incubation Time:96 hours
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Result:Dose-dependently suppressed the growth of both A549 and A549/1B10 cells, and statistically significant at 20 μM.
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Cell Line:CDDP-resistance (cisplatin-resisitance) of A549 cells
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Concentration:0, 10, 20, 40 μM
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Incubation Time:Pretreatment with AKR1B10-IN-1 for 2 hours, then incubated with CDDP for 24 hours
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Result:Decreased the cell viability of CDDP-R-A549 cells in a dose-dependent manner, and most obvious in the treatment of 40 μM.
Chemical Information
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CAS No. 2136579-33-2
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Appearance Solid
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Masse moléculaire 341.33
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Formule C19H16FNO4
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Color White to yellow
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SMILES
O=C(C1=CC2=CC=C(O)C=C2OC1=O)NCCCC3=CC=C(F)C=C3
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 100 mg/mL (292.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Pureté et documentation
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Fiche technique (270 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Instruction de manipulation (2659 KB)
Références
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.9297 mL | 14.6486 mL | 29.2972 mL | 73.2429 mL |
| 5 mM | 0.5859 mL | 2.9297 mL | 5.8594 mL | 14.6486 mL | |
| 10 mM | 0.2930 mL | 1.4649 mL | 2.9297 mL | 7.3243 mL | |
| 15 mM | 0.1953 mL | 0.9766 mL | 1.9531 mL | 4.8829 mL | |
| 20 mM | 0.1465 mL | 0.7324 mL | 1.4649 mL | 3.6621 mL | |
| 25 mM | 0.1172 mL | 0.5859 mL | 1.1719 mL | 2.9297 mL | |
| 30 mM | 0.0977 mL | 0.4883 mL | 0.9766 mL | 2.4414 mL | |
| 40 mM | 0.0732 mL | 0.3662 mL | 0.7324 mL | 1.8311 mL | |
| 50 mM | 0.0586 mL | 0.2930 mL | 0.5859 mL | 1.4649 mL | |
| 60 mM | 0.0488 mL | 0.2441 mL | 0.4883 mL | 1.2207 mL | |
| 80 mM | 0.0366 mL | 0.1831 mL | 0.3662 mL | 0.9155 mL | |
| 100 mM | 0.0293 mL | 0.1465 mL | 0.2930 mL | 0.7324 mL |
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