2016-36-6
Chemical Structure
Salicylate choline
- CAS No.: 2016-36-6
- Formula:C12H19NO4
- Molecular Weight:241.28
IUPAC Name: 2-hydroxy-N,N,N-trimethylethan-1-aminium 2-carboxyphenolate
InChIKey: UDKCHVLMFQVBAA-UHFFFAOYSA-M
SMILES: O=C(O)C1=CC=CC=C1[O-].C[N+](C)(CCO)C
Biological Activity: Salicylate choline is an orally active derivative of Aspirin (acetylsalicylic acid) (HY-14654). Salicylate choline significantly reduces IL-1β, IL-6, TNF-α and IL-10 levels in cells. Salicylate choline enhances the anti-tumor activity of the CRM1 inhibitor Selinexor (KPT-330) (HY-17536) through inducing S-phase cell cycle arrest and impairing DNA damage repair. Salicylate choline combined with Selinexor demonstrates excellent anti-tumor efficacy in mice xenograft model harboring JeKo-1 cells. Salicylate choline can be used for the study of rheumatic diseases, inflammation and cancer[1][2][3][4].
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Salicylate choline | Salicylate choline is an orally active derivative of Aspirin (acetylsalicylic acid) (HY-14654). Salicylate choline significantly reduces IL-1β, IL-6, TNF-α and IL-10 levels in cells. Salicylate choline enhances the anti-tumor activity of the CRM1 inhibitor Selinexor (KPT-330) (HY-17536) through inducing S-phase cell cycle arrest and impairing DNA damage repair. Salicylate choline combined with Selinexor demonstrates excellent anti-tumor efficacy in mice xenograft model harboring JeKo-1 cells. Salicylate choline can be used for the study of rheumatic diseases, inflammation and cancer. | |||||||||||||||||||||
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- [1]. Tiras M, et al. In vitro assessment of cytokine modulation by choline salicylate, hyaluronic acid, lidocaine-based six different teething gels in human gingival fibroblast cells. Odontology. 2025 May 13. [Content Brief]
- [2]. SCULLY FJ. Choline salicylate: an effective, well-tolerated drug for treatment of rheumatic diseases. South Med J. 1960 Jan;53:12-6. [Content Brief]
- [3]. Wróblewska KB, et al. Choline Salicylate Analysis: Chemical Stability and Degradation Product Identification. Molecules. 2019 Dec 22;25(1):51. [Content Brief]
- [4]. Abeykoon JP, et al. Salicylates enhance CRM1 inhibitor antitumor activity by induction of S-phase arrest and impairment of DNA-damage repair. Blood. 2021 Jan 28;137(4):513-523. [Content Brief]
Keywords
