Art. -Nr.: HY-14258A

Escitalopram oxalate

(Synonyms: (S)-Citalopram oxalate; (S)-(+)-Citalopram oxalate)

11 Cited Publications

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Based on 11 publication(s) in Google Scholar

Escitalopram ((S)-Citalopram) oxalate, the S-enantiomer of racemic Citalopram, is a selective serotonin reuptake inhibitor (SSRI) with a K_i of 0.89 nM. Escitalopram oxalate has ∼30 fold higher binding affinity than its R(-)-enantiomer and shows selectivity over both dopamine transporter (DAT) and norepinephrine transporter (NET). Escitalopram oxalate is an antidepressant for the research of major depression.

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Reinheit: 99.97%
CAS. Nr.: 219861-08-2
Formel: C₂₂H₂₃FN₂O₅
Molecular Weight:414.43

Speicherung:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Escitalopram oxalate Chemical Structure

CAS. Nr.: 219861-08-2

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vivo
Chemical Information
Publications (11)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

Ki: 0.89 nM (serotonin transporter), 10500 nM (DAT), 8150 nM (NET)^[1]

In Vivo

Escitalopram (10 mg/kg; i.p.; daily for 28 days) ameliorates cognitive impairments and selectively attenuates phosphorylated tau accumulation in stressed rats^[3].
Chronic administration of Escitalopram (daily; drinking water for a total of 4 months) significantly reduces plaque load by 28% and 34% at 2.5 and 5 mg/d, respectively ^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male Sprague-Dawley rats^[3]
Dosage:

10 mg/kg
Administration:

I.p.; daily for 28 days
Result:

Could selectively decrease phosphorylated tau accumulation in the hippocampus of stressed rats and could distinctly alleviate the hyperactivity of the HPA axis in both depressive and resistant rats.

Animal Model:

APP-PS1 hemizygous female mice (4 months of age)^[4]
Dosage:

2.5-5 mg/kg
Administration:

Daily; drinking water for a total of 4 months
Result:

At both doses significantly reduced plaque burden within the brains of these mice compared to littermate controls that drank only water. Hippocampal plaque load was significantly reduced by 28.7% and 34.4 % for ESC 2.5 mg/day and 5 mg/day, respectively.

Chemical Information

CAS. Nr. 219861-08-2
Appearance Solid
Molecular Weight 414.43
Formel C₂₂H₂₃FN₂O₅
Color White to off-white
SMILES

FC1=CC=C([C@@]2(CCCN(C)C)C(C=CC(C#N)=C3)=C3CO2)C=C1.O=C(O)C(O)=O
Synonyms

(S)-Citalopram oxalate; (S)-(+)-Citalopram oxalate
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (11)

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Journal Impact Factor

Phytomedicine

Ginsenoside Rb1 protects hippocampal neurons in depressed rats based on mitophagy-regulated astrocytic pyroptosis. [Abstract]

2023 Dec:121:155083. PMID: 37722244
Brain Behav Immun

Depression-related chronic stress promotes ovarian cancer progression via metabolic dysfunction and IRF1-mediated immune suppression. [Abstract]

2026 Jan 26:134:106471. PMID: 41605304
Transl Psychiatry

Association of escitalopram-induced shifts in gut microbiota and sphingolipid metabolism with depression-like behavior in wistar-kyoto rats. [Abstract]

2025 Feb 17;15(1):54. PMID: 39962083
Geroscience

Escitalopram accelerated aging via impaired IIS/autophagy signaling pathway. [Abstract]

2026 Mar 5. PMID: 41781498
Int Immunopharmacol

Innovative role of the antidepressant imipramine in esophageal squamous cell carcinoma treatment: Promoting apoptosis and protective autophagy. [Abstract]

2025 Jan 6:147:113969. PMID: 39764996
Mol Neurobiol

Ginsenoside Rg1 Reduced Microglial Activation and Mitochondrial Dysfunction to Alleviate Depression-Like Behaviour Via the GAS5/EZH2/SOCS3/NRF2 Axis. [Abstract]

2022 May;59(5):2855-2873. PMID: 35230663
Brain Sci

The pCREB/BDNF Pathway in the Hippocampus Is Involved in the Therapeutic Effect of Selective 5-HT Reuptake Inhibitors in Adult Male Rats Exposed to Blast Traumatic Brain Injury. [Abstract]

2025 Feb 24;15(3):236. PMID: 40149758
J Clin Psychopharmacol

Citalopram and Cannabidiol: In Vitro and In Vivo Evidence of Pharmacokinetic Interactions Relevant to the Treatment of Anxiety Disorders in Young People. [Abstract]

2021 Sep-Oct;41(5):525-533. PMID: 34121064
PLoS One

Untargeted metabolomics reveals quinic acid as the kiwifruit component that affects brain activity in mice. [Abstract]

2025 Aug 18;20(8):e0326134. PMID: 40824948
Brain Mechanisms

2025 Nov 21.
SSRN

2024 Oct 14.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 116.67 mg/mL (281.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : ≥ 14.29 mg/mL (34.48 mM)

* "≥" means soluble, but saturation unknown.

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.4130 mL

12.0648 mL

24.1295 mL

5 mM

0.4826 mL

2.4130 mL

4.8259 mL

10 mM

0.2413 mL

1.2065 mL

2.4130 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass

Konzentration

Volumen

Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)}

In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: ≥ 100 mg/mL (241.30 mM); Clear solution

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage
mg/kg
Animal Weight (Per Animal)
g
Dosing Volume (Per Animal)
μL
Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (280 KB)
SDS (458 KB)
- English - EN (458 KB)
- Français - FR (458 KB)
- Deutsch - DE (458 KB)
- Norwegian - NO (458 KB)
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- Swedish - SV (458 KB)
- Italian - IT (458 KB)
- Portuguese - PT (458 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Zhang, P., et al., Structure-activity relationships for a novel series of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbon itrile) analogues at monoamine transporters. J Med Chem, 2010. 53(16): p. 6112-21. [Content Brief]

[2]. Pastoor, D. and J. Gobburu, Clinical pharmacology review of escitalopram for the treatment of depression. Expert Opin Drug Metab Toxicol, 2014. 10(1): p. 121-8. [Content Brief]

[3]. Wu C , et al. Escitalopram alleviates stress-induced Alzheimer's disease-like tau pathologies and cognitive deficits by reducing hypothalamic-pituitary-adrenal axis reactivity and insulin/GSK-3β signal pathway activity. Neurobiol Aging. 2018;67:137-147. [Content Brief]

[4]. Cirrito JR, et al. Effect of escitalopram on Aβ levels and plaque load in an Alzheimer mouse model. Neurology. 2020;95(19):e2666-e2674. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	2.4130 mL	12.0648 mL	24.1295 mL	60.3238 mL
	5 mM	0.4826 mL	2.4130 mL	4.8259 mL	12.0648 mL
	10 mM	0.2413 mL	1.2065 mL	2.4130 mL	6.0324 mL
	15 mM	0.1609 mL	0.8043 mL	1.6086 mL	4.0216 mL
	20 mM	0.1206 mL	0.6032 mL	1.2065 mL	3.0162 mL
	25 mM	0.0965 mL	0.4826 mL	0.9652 mL	2.4130 mL
	30 mM	0.0804 mL	0.4022 mL	0.8043 mL	2.0108 mL
DMSO	40 mM	0.0603 mL	0.3016 mL	0.6032 mL	1.5081 mL
	50 mM	0.0483 mL	0.2413 mL	0.4826 mL	1.2065 mL
	60 mM	0.0402 mL	0.2011 mL	0.4022 mL	1.0054 mL
	80 mM	0.0302 mL	0.1508 mL	0.3016 mL	0.7540 mL
	100 mM	0.0241 mL	0.1206 mL	0.2413 mL	0.6032 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Escitalopram oxalate

11 Cited Publications

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Escitalopram oxalate

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Publications Citing Use of MedChemExpress (MCE) Escitalopram oxalate

Biologische Aktivität

Chemical Information

Publications (11)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Escitalopram oxalate Related Classifications

Art. -Nr.: HY-14258A