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Art. -Nr.: HY-114424

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H-Ile-Pro-Pro-OH

1 Cited Publications

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H-Ile-Pro-Pro-OH, a milk-derived peptide, inhibits angiotensin-converting enzyme (ACE) with an IC₅₀ of 5 μM. Antihypertensive tripeptides.

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CAS. Nr.: 26001-32-1
Formel: C₁₆H₂₇N₃O₄
Molecular Weight:325.40

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

H-Ile-Pro-Pro-OH Chemical Structure

CAS. Nr.: 26001-32-1

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Reinheit & Dokumentation
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Calculators
Help & FAQs
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Biologische Aktivität

Beschreibung

H-Ile-Pro-Pro-OH, a milk-derived peptide^[1], inhibits angiotensin-converting enzyme (ACE)^[1] with an IC₅₀ of 5 μM^[2]. Antihypertensive tripeptides^[1].

IC₅₀ & Target

IC50: 5 μM (ACE)^[2]

In Vitro

Ile-Pro-Pro (IPP; 1 nM, 0.1 μM, and 10 μM) increases nitric oxide (NO) production in human umbilical vein endothelial cells (HUVECs)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Ile-Pro-Pro (IPP; 30 mg/kg per day; 0.3 g/L) attenuates arterial dysfunction in L-NAME-treated rats^[1]
Ile-Pro-Pro decreases blood pressure in spontaneously hypertensive rats (SHR) ^[1].
Ile-Pro-Pro attenuates the development of atherosclerosis in apolipoprotein E-deficient (apoE(-/-)) mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 26001-32-1
Molecular Weight 325.40
Formel C₁₆H₂₇N₃O₄
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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J Physiol Biochem

Ile-Pro-Pro attenuates sympathetic activity and hypertension. [Abstract]

2024 Aug;80(3):585-598. PMID: 39008241

Reinheit & Dokumentation

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Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Nonaka A, et al. The milk-derived peptides Val-Pro-Pro and Ile-Pro-Pro attenuate arterial dysfunction in L-NAME-treated rats. Hypertens Res. 2014 Aug;37(8):703-7. [Content Brief]

[2]. Nakamura Y, et al. Purification and characterization of angiotensin I-converting enzyme inhibitors from sour milk. J Dairy Sci. 1995 Apr;78(4):777-83. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

H-Ile-Pro-Pro-OH

1 Cited Publications

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Biologische Aktivität
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- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Reinheit & Dokumentation
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H-Ile-Pro-Pro-OH

Publications Citing Use of MedChemExpress (MCE) H-Ile-Pro-Pro-OH

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Chemical Information

Publications (1)

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H-Ile-Pro-Pro-OH Related Classifications

Art. -Nr.: HY-114424