Azidoethyl-SS-ethylamine
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Azidoethyl-SS-ethylamine is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Azidoethyl-SS-ethylamine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
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- Reinheit: 98.0%
- CAS. Nr.: 1807512-40-8
- Formel: C4H10N4S2
- Molecular Weight:178.28
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Speicherung:Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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Disulfide Cleavable Linker |
Cleavable Linker |
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS. Nr. 1807512-40-8
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Appearance Liquid
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Molecular Weight 178.28
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Formel C4H10N4S2
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Color Light yellow to yellow
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SMILES
NCCSSCCN=[N+]=[N-]
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Pure form -20°C 3 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
DMSO : 250 mg/mL (1402.29 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Working solution concentration: 0.22 mg/mL
Reinheit & Dokumentation
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Data Sheet (266 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
Verweise
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 5.6092 mL | 28.0458 mL | 56.0915 mL | 140.2289 mL |
| 5 mM | 1.1218 mL | 5.6092 mL | 11.2183 mL | 28.0458 mL | |
| 10 mM | 0.5609 mL | 2.8046 mL | 5.6092 mL | 14.0229 mL | |
| 15 mM | 0.3739 mL | 1.8697 mL | 3.7394 mL | 9.3486 mL | |
| 20 mM | 0.2805 mL | 1.4023 mL | 2.8046 mL | 7.0114 mL | |
| 25 mM | 0.2244 mL | 1.1218 mL | 2.2437 mL | 5.6092 mL | |
| 30 mM | 0.1870 mL | 0.9349 mL | 1.8697 mL | 4.6743 mL | |
| 40 mM | 0.1402 mL | 0.7011 mL | 1.4023 mL | 3.5057 mL | |
| 50 mM | 0.1122 mL | 0.5609 mL | 1.1218 mL | 2.8046 mL | |
| 60 mM | 0.0935 mL | 0.4674 mL | 0.9349 mL | 2.3371 mL | |
| 80 mM | 0.0701 mL | 0.3506 mL | 0.7011 mL | 1.7529 mL | |
| 100 mM | 0.0561 mL | 0.2805 mL | 0.5609 mL | 1.4023 mL |
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